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Gene: MAP3K7 (mitogen-activated protein kinase kinase kinase 7) Homo sapiens
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Symbol: MAP3K7
Name: mitogen-activated protein kinase kinase kinase 7
Description: Exhibits several functions, including MAP kinase kinase kinase activity; receptor tyrosine kinase binding activity; and scaffold protein binding activity. Involved in cellular protein modification process; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Localizes to Ada2/Gcn5/Ada3 transcription activator complex; cytosol; and plasma membrane. Colocalizes with IkappaB kinase complex. Implicated in frontometaphyseal dysplasia 2 and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CSCF; FMD2; MEKK7; TAK1; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; TGF1a; transforming growth factor-beta-activated kinase 1
Orthologs:
Mus musculus (house mouse) : Map3k7 (mitogen-activated protein kinase kinase kinase 7)  MGI  Alliance
Rattus norvegicus (Norway rat) : Map3k7 (mitogen activated protein kinase kinase kinase 7)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map3k7 (mitogen-activated protein kinase kinase kinase 7)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP3K7 (mitogen-activated protein kinase kinase kinase 7)
Canis lupus familiaris (dog) : MAP3K7 (mitogen-activated protein kinase kinase kinase 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map3k7 (mitogen-activated protein kinase kinase kinase 7)
Sus scrofa (pig) : MAP3K7 (mitogen-activated protein kinase kinase kinase 7)
Chlorocebus sabaeus (African green monkey) : MAP3K7 (mitogen-activated protein kinase kinase kinase 7)
Heterocephalus glaber (naked mole-rat) : Map3k7 (mitogen-activated protein kinase kinase kinase 7)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl690,513,573 - 90,587,072 (-)EnsemblGRCh38hg38GRCh38
GRCh38690,513,579 - 90,587,072 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37691,223,292 - 91,297,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36691,282,074 - 91,353,628 (-)NCBINCBI36hg18NCBI36
Celera691,646,249 - 91,717,462 (-)NCBI
Cytogenetic Map6q15NCBI
HuRef688,442,517 - 88,515,844 (-)NCBIHuRef
CHM1_1691,320,725 - 91,394,113 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
 
More on MAP3K7
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319782
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.