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Gene: DDX58 (DExD/H-box helicase 58) Homo sapiens
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Symbol: DDX58
Name: DExD/H-box helicase 58
Description: Exhibits several functions, including RNA binding activity; ubiquitin protein ligase binding activity; and zinc ion binding activity. Involved in several processes, including cellular response to exogenous dsRNA; positive regulation of cytokine production; and regulation of transcription, DNA-templated. Localizes to several cellular components, including the actin cytoskeleton; bicellular tight junction; and ruffle membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; DEAD box protein 58; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; DKFZp434J1111; DKFZp686N19181; FLJ13599; probable ATP-dependent RNA helicase DDX58; retinoic acid inducible gene I; retinoic acid-inducible gene 1 protein; retinoic acid-inducible gene I protein; RIG-1; RIG-I; RIG-I-like receptor 1; RIG1; RIGI; RLR-1; RNA helicase RIG-I; SGMRT2
Orthologs:
Mus musculus (house mouse) : Ddx58 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 58)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddx58 (DEXD/H-box helicase 58)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddx58 (DExD/H-box helicase 58)
Pan paniscus (bonobo/pygmy chimpanzee) : DDX58 (DExD/H-box helicase 58)
Canis lupus familiaris (dog) : DDX58 (DExD/H-box helicase 58)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddx58 (DExD/H-box helicase 58)
Sus scrofa (pig) : DDX58 (DExD/H-box helicase 58)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: RARRES3 (Gene ID: 5920) and DDX58 (Gene ID: 23586) share the RIG1/RIG-1 alias in common. RIG1 is a widely used alternative name for DExD/H-box helicase 58 (DDX58), which can be confused with the retinoic acid receptor responder 3 (RARRES3) gene, since they share the same alias. [22 Jan 2019]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38932,455,302 - 32,526,196 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37932,455,300 - 32,526,322 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36932,445,300 - 32,516,322 (-)NCBINCBI36hg18NCBI36
Build 34932,445,704 - 32,516,322NCBI
Celera932,385,259 - 32,456,256 (-)NCBI
Cytogenetic Map9p21.1NCBI
HuRef932,411,092 - 32,481,542 (-)NCBIHuRef
CHM1_1932,455,159 - 32,526,318 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DDX58
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319812
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.