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Gene: DDX58 (DExD/H-box helicase 58) Homo sapiens
Symbol: DDX58
Name: DExD/H-box helicase 58
Description: Exhibits several functions, including RNA binding activity; ubiquitin protein ligase binding activity; and zinc ion binding activity. Involved in several processes, including cellular response to exogenous dsRNA; positive regulation of cytokine production; and regulation of transcription, DNA-templated. Localizes to several cellular components, including the actin cytoskeleton; bicellular tight junction; and ruffle membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; DEAD box protein 58; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; DKFZp434J1111; DKFZp686N19181; FLJ13599; probable ATP-dependent RNA helicase DDX58; retinoic acid inducible gene I; retinoic acid-inducible gene 1 protein; retinoic acid-inducible gene I protein; RIG-1; RIG-I; RIG-I-like receptor 1; RIG1; RIGI; RLR-1; RNA helicase RIG-I; SGMRT2
Mus musculus (house mouse) : Ddx58 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 58)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddx58 (DEXD/H-box helicase 58)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddx58 (DExD/H-box helicase 58)
Pan paniscus (bonobo/pygmy chimpanzee) : DDX58 (DExD/H-box helicase 58)
Canis lupus familiaris (dog) : DDX58 (DExD/H-box helicase 58)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddx58 (DExD/H-box helicase 58)
Sus scrofa (pig) : DDX58 (DExD/H-box helicase 58)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: RARRES3 (Gene ID: 5920) and DDX58 (Gene ID: 23586) share the RIG1/RIG-1 alias in common. RIG1 is a widely used alternative name for DExD/H-box helicase 58 (DDX58), which can be confused with the retinoic acid receptor responder 3 (RARRES3) gene, since they share the same alias. [22 Jan 2019]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38932,455,302 - 32,526,196 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37932,455,300 - 32,526,322 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36932,445,300 - 32,516,322 (-)NCBINCBI36hg18NCBI36
Build 34932,445,704 - 32,516,322NCBI
Celera932,385,259 - 32,456,256 (-)NCBI
Cytogenetic Map9p21.1NCBI
HuRef932,411,092 - 32,481,542 (-)NCBIHuRef
CHM1_1932,455,159 - 32,526,318 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DDX58
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319812
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.