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Gene: EXO1 (exonuclease 1) Homo sapiens
Symbol: EXO1
Name: exonuclease 1
Description: This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: exonuclease I; HEX1; hExo1; hExoI; rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
Mus musculus (house mouse) : Exo1 (exonuclease 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Exo1 (exonuclease 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Exo1 (exonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EXO1 (exonuclease 1)
Canis lupus familiaris (dog) : EXO1 (exonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Exo1 (exonuclease 1)
Sus scrofa (pig) : EXO1 (exonuclease 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381241,847,967 - 241,889,939 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371242,011,491 - 242,053,241 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361240,078,158 - 240,119,671 (+)NCBINCBI36hg18NCBI36
Build 341238,337,575 - 238,379,088NCBI
Celera1215,267,055 - 215,308,778 (+)NCBI
Cytogenetic Map1q43NCBI
HuRef1212,470,280 - 212,512,011 (+)NCBIHuRef
CHM1_11243,284,062 - 243,325,806 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on EXO1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319820
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.