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Gene: SOX4 (SRY-box transcription factor 4) Homo sapiens
Symbol: SOX4
Name: SRY-box transcription factor 4
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of gene expression; and protein stabilization. Localizes to the mitochondrion and nucleoplasm. Implicated in Coffin-Siris syndrome and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CSS10; ecotropic viral integration site 16; EVI16; SRY (sex determining region Y)-box 4; SRY box 4; SRY-box 4; SRY-related HMG-box gene 4; transcription factor SOX-4
Mus musculus (house mouse) : Sox4 (SRY (sex determining region Y)-box 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sox4 (SRY-box transcription factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sox4 (SRY-box transcription factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SOX4 (SRY-box transcription factor 4)
Canis lupus familiaris (dog) : SOX4 (SRY-box transcription factor 4)
Sus scrofa (pig) : SOX4 (SRY-box transcription factor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38621,593,751 - 21,598,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37621,593,972 - 21,598,850 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36621,701,951 - 21,706,829 (+)NCBINCBI36hg18NCBI36
Build 34621,701,950 - 21,706,826NCBI
Celera622,827,304 - 22,832,182 (+)NCBI
Cytogenetic Map6p22.3NCBI
HuRef621,537,779 - 21,542,257 (+)NCBIHuRef
CHM1_1621,596,072 - 21,600,948 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SOX4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319854
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.