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Gene: SOX4 (SRY-box transcription factor 4) Homo sapiens
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Symbol: SOX4
Name: SRY-box transcription factor 4
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of gene expression; and protein stabilization. Localizes to the mitochondrion and nucleoplasm. Implicated in Coffin-Siris syndrome and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CSS10; ecotropic viral integration site 16; EVI16; SRY (sex determining region Y)-box 4; SRY box 4; SRY-box 4; SRY-related HMG-box gene 4; transcription factor SOX-4
Orthologs:
Mus musculus (house mouse) : Sox4 (SRY (sex determining region Y)-box 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sox4 (SRY-box transcription factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sox4 (SRY-box transcription factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SOX4 (SRY-box transcription factor 4)
Canis lupus familiaris (dog) : SOX4 (SRY-box transcription factor 4)
Sus scrofa (pig) : SOX4 (SRY-box transcription factor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38621,593,751 - 21,598,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37621,593,972 - 21,598,850 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36621,701,951 - 21,706,829 (+)NCBINCBI36hg18NCBI36
Build 34621,701,950 - 21,706,826NCBI
Celera622,827,304 - 22,832,182 (+)NCBI
Cytogenetic Map6p22.3NCBI
HuRef621,537,779 - 21,542,257 (+)NCBIHuRef
CHM1_1621,596,072 - 21,600,948 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SOX4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319854
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.