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Gene: ITM2C (integral membrane protein 2C) Homo sapiens
Symbol: ITM2C
Name: integral membrane protein 2C
Description: Exhibits amyloid-beta binding activity. Involved in negative regulation of neuron projection development and neuron differentiation. Localizes to several cellular components, including the Golgi apparatus; lysosome; and perinuclear region of cytoplasm; INTERACTS WITH 17beta-estradiol; 2-methylcholine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BRI3; BRICD2C; BRICHOS domain containing 2C; cerebral protein 14; E25; E25C; hRPC.1050_D_4; integral membrane protein 3; ITM3; transmembrane protein BRI3
Mus musculus (house mouse) : Itm2c (integral membrane protein 2C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itm2c (integral membrane protein 2C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itm2c (integral membrane protein 2C)
Pan paniscus (bonobo/pygmy chimpanzee) : ITM2C (integral membrane protein 2C)
Canis lupus familiaris (dog) : ITM2C (integral membrane protein 2C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itm2c (integral membrane protein 2C)
Sus scrofa (pig) : ITM2C (integral membrane protein 2C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382230,864,185 - 230,879,254 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372231,729,546 - 231,743,963 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,437,865 - 231,452,207 (+)NCBINCBI36hg18NCBI36
Build 342231,555,125 - 231,569,467NCBI
Celera2225,506,038 - 225,520,369 (+)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2223,571,781 - 223,586,111 (+)NCBIHuRef
CHM1_12231,735,141 - 231,749,777 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ITM2C
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319877
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.