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Gene: NECTIN2 (nectin cell adhesion molecule 2) Homo sapiens
Symbol: NECTIN2
Name: nectin cell adhesion molecule 2
Description: Exhibits cell adhesion molecule binding activity and protein homodimerization activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of immune response; and viral life cycle. Localizes to the cell surface; cell-cell junction; and integral component of membrane. Implicated in Alzheimer's disease and multiple sclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD112; herpes virus entry mediator B; herpesvirus entry mediator B; herpesvirus entry protein B; HVEB; nectin 2; nectin-2; poliovirus receptor related 2; poliovirus receptor-like 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); poliovirus receptor-related protein 2; PRR2; PVRL2; PVRR2
Mus musculus (house mouse) : Nectin2 (nectin cell adhesion molecule 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nectin2 (nectin cell adhesion molecule 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nectin2 (nectin cell adhesion molecule 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NECTIN2 (nectin cell adhesion molecule 2)
Canis lupus familiaris (dog) : NECTIN2 (nectin cell adhesion molecule 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nectin2 (nectin cell adhesion molecule 2)
Sus scrofa (pig) : NECTIN2 (nectin cell adhesion molecule 2)
Chlorocebus sabaeus (African green monkey) : NECTIN2 (nectin cell adhesion molecule 2)
Heterocephalus glaber (naked mole-rat) : Nectin2 (nectin cell adhesion molecule 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1944,846,175 - 44,889,223 (+)EnsemblGRCh38hg38GRCh38
GRCh381944,846,297 - 44,889,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371945,349,393 - 45,392,485 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,041,233 - 50,084,325 (+)NCBINCBI36hg18NCBI36
Build 341950,041,473 - 50,074,034NCBI
Celera1942,153,754 - 42,196,828 (+)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1941,779,725 - 41,822,792 (+)NCBIHuRef
CHM1_11945,352,150 - 45,395,259 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NECTIN2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319880
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.