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Gene: IRAK2 (interleukin 1 receptor associated kinase 2) Homo sapiens
Symbol: IRAK2
Name: interleukin 1 receptor associated kinase 2
Description: Exhibits protein heterodimerization activity and protein homodimerization activity. Involved in interleukin-1-mediated signaling pathway; regulation of DNA-binding transcription factor activity; and regulation of cytokine-mediated signaling pathway. Predicted to localize to the cytoplasm and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: interleukin-1 receptor associated kinase-2; interleukin-1 receptor-associated kinase 2; interleukin-1 receptor-associated kinase-like 2; IRAK-2; MGC150550
Mus musculus (house mouse) : Irak2 (interleukin-1 receptor-associated kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irak2 (interleukin-1 receptor-associated kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irak2 (interleukin 1 receptor associated kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IRAK2 (interleukin 1 receptor associated kinase 2)
Canis lupus familiaris (dog) : IRAK2 (interleukin 1 receptor associated kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irak2 (interleukin 1 receptor associated kinase 2)
Sus scrofa (pig) : IRAK2 (interleukin 1 receptor associated kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl310,164,919 - 10,243,745 (+)Ensembl
GRCh38310,164,919 - 10,243,745 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37310,206,561 - 10,285,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36310,181,563 - 10,260,427 (+)NCBINCBI36hg18NCBI36
Build 34310,181,562 - 10,260,427NCBI
Celera310,142,206 - 10,221,236 (+)NCBI
Cytogenetic Map3p25.3NCBI
HuRef310,142,464 - 10,221,162 (+)NCBIHuRef
CHM1_1310,156,570 - 10,235,592 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IRAK2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319999
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.