Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: SORBS1 (sorbin and SH3 domain containing 1) Homo sapiens
Analyze
Symbol: SORBS1
Name: sorbin and SH3 domain containing 1
CRRD ID: 1320080
Description: Exhibits insulin receptor binding activity and signaling receptor complex adaptor activity. Predicted to be involved in several processes, including cellular response to hormone stimulus; positive regulation of biosynthetic process; and regulation of protein localization to membrane. Localizes to centrosome; focal adhesion; and nucleus. Implicated in obesity and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-Cbl associated protein; c-Cbl-associated protein; CAP; DKFZp451C066; DKFZp586P1422; Fas-ligand associated factor 2; FLAF2; FLJ12406; KIAA1296; ponsin; R85FL; SH3 domain protein 5; SH3-domain protein 5 (ponsin); SH3D5; SH3P12; SORB1; sorbin and SH3 domain-containing protein 1
Orthologs:
Mus musculus (house mouse) : Sorbs1 (sorbin and SH3 domain containing 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sorbs1 (sorbin and SH3 domain containing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sorbs1 (sorbin and SH3 domain containing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SORBS1 (sorbin and SH3 domain containing 1)
Canis lupus familiaris (dog) : SORBS1 (sorbin and SH3 domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sorbs1 (sorbin and SH3 domain containing 1)
Sus scrofa (pig) : SORBS1 (sorbin and SH3 domain containing 1)
Chlorocebus sabaeus (African green monkey) : SORBS1 (sorbin and SH3 domain containing 1)
Heterocephalus glaber (naked mole-rat) : Sorbs1 (sorbin and SH3 domain containing 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1095,311,771 - 95,561,414 (-)EnsemblGRCh38hg38GRCh38
GRCh381095,311,773 - 95,561,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371097,071,530 - 97,321,171 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361097,061,520 - 97,311,161 (-)NCBINCBI36hg18NCBI36
Build 341097,061,520 - 97,311,125NCBI
Celera1090,812,720 - 91,062,378 (-)NCBI
Cytogenetic Map10q24.1NCBI
HuRef1090,698,450 - 90,948,671 (-)NCBIHuRef
CHM1_11097,353,333 - 97,602,955 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SORBS1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320080
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.