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Gene: Tlx2 (T cell leukemia, homeobox 2) Mus musculus
Symbol: Tlx2
Name: T cell leukemia, homeobox 2
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in enteric nervous system development; mesoderm formation; and negative regulation of dendrite morphogenesis. Localizes to cytoplasm and nucleus. Used to study neuronal intestinal dysplasia. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; primitive streak; and urethra. Orthologous to human TLX2 (T cell leukemia homeobox 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: enteric neuron homeobox; Enx; homeo box 11-like 1; homeobox protein Hox-11L1; homeobox TLX-2; Hox11L.1; Hox11l1; NCX; Ncx1; PMUR10F; T-cell leukemia homeobox protein 2; T-cell leukemia, homeobox 2; Tlx1l1; Tlx1l2
Homo sapiens (human) : TLX2 (T cell leukemia homeobox 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tlx2 (T-cell leukemia homeobox 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlx2 (T cell leukemia homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TLX2 (T cell leukemia homeobox 2)
Canis lupus familiaris (dog) : TLX2 (T cell leukemia homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlx2 (T cell leukemia homeobox 2)
Sus scrofa (pig) : TLX2 (T cell leukemia homeobox 2)
Chlorocebus sabaeus (African green monkey) : TLX2 (T cell leukemia homeobox 2)
Heterocephalus glaber (naked mole-rat) : Tlx2 (T cell leukemia homeobox 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl683,068,324 - 83,070,293 (-)EnsemblGRCm38mm10GRCm38
GRCm38683,068,325 - 83,070,225 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37683,018,319 - 83,020,219 (-)NCBIGRCm37mm9NCBIm37
MGSCv36683,033,983 - 83,035,883 (-)NCBImm8
Celera685,050,935 - 85,052,835 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Tlx2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320083
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.