Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: IRF6 (interferon regulatory factor 6) Homo sapiens
Analyze
Symbol: IRF6
Name: interferon regulatory factor 6
Description: This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IRF-6; LPS; OFC6; PIT; PPS; PPS1; Van der Woude syndrome; VWS; VWS1
Orthologs:
Mus musculus (house mouse) : Irf6 (interferon regulatory factor 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irf6 (interferon regulatory factor 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf6 (interferon regulatory factor 6)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF6 (interferon regulatory factor 6)
Canis lupus familiaris (dog) : IRF6 (interferon regulatory factor 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf6 (interferon regulatory factor 6)
Sus scrofa (pig) : IRF6 (interferon regulatory factor 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381209,785,617 - 209,806,175 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371209,958,968 - 209,979,520 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361208,027,885 - 208,046,102 (-)NCBINCBI36hg18NCBI36
Build 341206,349,656 - 206,367,874NCBI
Celera1183,192,156 - 183,210,363 (-)NCBI
Cytogenetic Map1q32.2NCBI
HuRef1180,634,114 - 180,654,661 (-)NCBIHuRef
CHM1_11211,231,296 - 211,251,831 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on IRF6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320095
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-17
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.