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Gene: IRF6 (interferon regulatory factor 6) Homo sapiens
Symbol: IRF6
Name: interferon regulatory factor 6
Description: This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IRF-6; LPS; OFC6; PIT; PPS; PPS1; Van der Woude syndrome; VWS; VWS1
Mus musculus (house mouse) : Irf6 (interferon regulatory factor 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irf6 (interferon regulatory factor 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf6 (interferon regulatory factor 6)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF6 (interferon regulatory factor 6)
Canis lupus familiaris (dog) : IRF6 (interferon regulatory factor 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf6 (interferon regulatory factor 6)
Sus scrofa (pig) : IRF6 (interferon regulatory factor 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381209,785,617 - 209,806,175 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371209,958,968 - 209,979,520 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361208,027,885 - 208,046,102 (-)NCBINCBI36hg18NCBI36
Build 341206,349,656 - 206,367,874NCBI
Celera1183,192,156 - 183,210,363 (-)NCBI
Cytogenetic Map1q32.2NCBI
HuRef1180,634,114 - 180,654,661 (-)NCBIHuRef
CHM1_11211,231,296 - 211,251,831 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IRF6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320095
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.