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Gene: Magel2 (melanoma antigen, family L, 2) Mus musculus
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Symbol: Magel2
Name: melanoma antigen, family L, 2
Description: Predicted to have ubiquitin-protein transferase activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of actin nucleation; and regulation of circadian rhythm. Localizes to cytoplasm and nucleus. Predicted to colocalize with retromer complex. Used to study Prader-Willi syndrome. Human ortholog(s) of this gene implicated in Schaaf-Yang syndrome. Is expressed in several structures, including brain; egg cylinder; reproductive system; turbinate bone primordium; and vertebral axis musculature. Orthologous to human MAGEL2 (MAGE family member L2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; pirinixic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Mage-l2; MAGE-like protein 2; melanoma antigen-like gene 2; NDNL1; necdin-like 1; nM15; ns7
Orthologs:
Homo sapiens (human) : MAGEL2 (MAGE family member L2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Magel2 (MAGE family member L2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Magel2 (MAGE family member L2)
Pan paniscus (bonobo/pygmy chimpanzee) : MAGEL2 (MAGE family member L2)
Canis lupus familiaris (dog) : MAGEL2 (MAGE family member L2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Magel2 (MAGE family member L2)
Sus scrofa (pig) : MAGEL2 (MAGE family member L2)
Chlorocebus sabaeus (African green monkey) : MAGEL2 (MAGE family member L2)
Heterocephalus glaber (naked mole-rat) : Magel2 (MAGE family member L2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl762,377,010 - 62,381,640 (+)EnsemblGRCm38mm10GRCm38
GRCm38762,376,979 - 62,381,640 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37769,521,865 - 69,526,526 (+)NCBIGRCm37mm9NCBIm37
MGSCv36751,738,184 - 51,742,845 (+)NCBImm8
MGSCv36762,255,929 - 62,260,590 (+)NCBImm8
Cytogenetic Map7CNCBI
cM Map734.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Magel2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320099
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.