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Gene: Rhbdf2 (rhomboid 5 homolog 2) Mus musculus
Symbol: Rhbdf2
Name: rhomboid 5 homolog 2
Description: Involved in negative regulation of protein secretion. Localizes to endoplasmic reticulum membrane. Used to study nonepidermolytic palmoplantar keratoderma. Human ortholog(s) of this gene implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. Orthologous to human RHBDF2 (rhomboid 5 homolog 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; 4-nonylphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4732465I17Rik; cub; inactive rhomboid protein 2; iRhom2; Rhbdl6; rhomboid family member 2; rhomboid veinlet-like protein 6; rhomboid, veinlet-like 6; rhomboid-like protein 6; rhomboid-related protein
Homo sapiens (human) : RHBDF2 (rhomboid 5 homolog 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rhbdf2 (rhomboid 5 homolog 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rhbdf2 (rhomboid 5 homolog 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RHBDF2 (rhomboid 5 homolog 2)
Canis lupus familiaris (dog) : RHBDF2 (rhomboid 5 homolog 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rhbdf2 (rhomboid 5 homolog 2)
Sus scrofa (pig) : RHBDF2 (rhomboid 5 homolog 2)
Chlorocebus sabaeus (African green monkey) : RHBDF2 (rhomboid 5 homolog 2)
Heterocephalus glaber (naked mole-rat) : Rhbdf2 (rhomboid 5 homolog 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl11116,598,165 - 116,627,019 (-)EnsemblGRCm38mm10GRCm38
GRCm3811116,598,148 - 116,626,960 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711116,459,479 - 116,488,333 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611116,414,259 - 116,443,109 (-)NCBImm8
Celera11128,368,470 - 128,397,196 (-)NCBICelera
Cytogenetic Map11E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Rhbdf2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320183
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.