Gene: CD209 (CD209 molecule) Homo sapiens
Symbol: CD209
Name: CD209 molecule
Description: This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; CD209 antigen; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; HIV gpl20-binding protein; MGC129965
Rattus norvegicus (Norway rat) : Cd209 (CD209 molecule)  Alliance
Canis lupus familiaris (dog) : CD209 (CD209 molecule)
Sus scrofa (pig) : CD209 (CD209 molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38197,739,993 - 7,747,609 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37197,804,879 - 7,812,499 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,710,882 - 7,718,406 (-)NCBINCBI36hg18NCBI36
Build 34197,710,881 - 7,718,406NCBI
Celera197,676,294 - 7,683,878 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef197,474,941 - 7,482,525 (-)NCBIHuRef
CHM1_1197,804,605 - 7,812,189 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CD209
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320216
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-06-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.