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Gene: Dvl2 (dishevelled segment polarity protein 2) Mus musculus
Symbol: Dvl2
Name: dishevelled segment polarity protein 2
Description: Exhibits several functions, including enzyme binding activity; frizzled binding activity; and identical protein binding activity. Involved in several processes, including embryonic morphogenesis; positive regulation of GTPase activity; and positive regulation of protein kinase activity. Localizes to several cellular components, including the apical part of cell; clathrin-coated vesicle; and lateral plasma membrane. Used to study dextro-looped transposition of the great arteries 1. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and retina. Orthologous to human DVL2 (dishevelled segment polarity protein 2); PARTICIPATES IN basal cell carcinoma pathway; Notch signaling pathway; Wnt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dishevelled 2, dsh homolog; dishevelled-2; DSH homolog 2; segment polarity protein dishevelled homolog DVL-2
Homo sapiens (human) : DVL2 (dishevelled segment polarity protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dvl2 (dishevelled segment polarity protein 2)
Chinchilla lanigera (long-tailed chinchilla) : Dvl2 (dishevelled segment polarity protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DVL2 (dishevelled segment polarity protein 2)
Canis lupus familiaris (dog) : DVL2 (dishevelled segment polarity protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dvl2 (dishevelled segment polarity protein 2)
Sus scrofa (pig) : DVL2 (dishevelled segment polarity protein 2)
Chlorocebus sabaeus (green monkey) : DVL2 (dishevelled segment polarity protein 2)
Heterocephalus glaber (naked mole-rat) : Dvl2 (dishevelled segment polarity protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1170,000,595 - 70,012,301 (+)Ensembl
GRCm381170,000,592 - 70,010,109 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371169,814,128 - 69,823,611 (+)NCBIGRCm37mm9NCBIm37
MGSCv361169,816,821 - 69,826,304 (+)NCBImm8
Celera1177,548,436 - 77,558,061 (+)NCBICelera
Cytogenetic Map11 B3NCBI
cM Map1142.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Dvl2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320220
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.