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Gene: TREM2 (triggering receptor expressed on myeloid cells 2) Homo sapiens
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Symbol: TREM2
Name: triggering receptor expressed on myeloid cells 2
Description: Exhibits several functions, including amyloid-beta binding activity; apolipoprotein A-I binding activity; and lipoprotein particle binding activity. Involved in several processes, including leukocyte differentiation; positive regulation of signal transduction; and positive regulation of transport. Localizes to the integral component of membrane and intrinsic component of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a
Orthologs:
Mus musculus (house mouse) : Trem2 (triggering receptor expressed on myeloid cells 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Trem2 (triggering receptor expressed on myeloid cells 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trem2 (triggering receptor expressed on myeloid cells 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TREM2 (triggering receptor expressed on myeloid cells 2)
Canis lupus familiaris (dog) : TREM2 (triggering receptor expressed on myeloid cells 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trem2 (triggering receptor expressed on myeloid cells 2)
Sus scrofa (pig) : TREM2 (triggering receptor expressed on myeloid cells 2)
Chlorocebus sabaeus (African green monkey) : TREM2 (triggering receptor expressed on myeloid cells 2)
Heterocephalus glaber (naked mole-rat) : Trem2 (triggering receptor expressed on myeloid cells 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl641,158,506 - 41,163,186 (-)EnsemblGRCh38hg38GRCh38
GRCh38641,158,508 - 41,163,116 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37641,126,244 - 41,130,924 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,234,230 - 41,238,892 (-)NCBINCBI36hg18NCBI36
Build 34641,234,230 - 41,238,892NCBI
Celera642,678,948 - 42,683,624 (-)NCBI
Cytogenetic Map6p21.1NCBI
HuRef640,844,044 - 40,848,724 (-)NCBIHuRef
CHM1_1641,129,139 - 41,133,819 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TREM2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320401
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.