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Gene: Lig3 (ligase III, DNA, ATP-dependent) Mus musculus
Symbol: Lig3
Name: ligase III, DNA, ATP-dependent
CRRD ID: 1320453
Description: Predicted to have DNA ligase (ATP) activity. Involved in double-strand break repair via alternative nonhomologous end joining; mitochondrial DNA repair; and negative regulation of DNA recombination. Localizes to synaptonemal complex. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human LIG3 (DNA ligase 3); PARTICIPATES IN nucleotide excision repair pathway; base excision repair pathway; INTERACTS WITH 17alpha-ethynylestradiol; 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D11Wsu78; D11Wsu78e; DNA ligase (ATP) 3; DNA ligase 3; DNA ligase III; MGC78176; polydeoxyribonucleotide synthase [ATP] 3
Homo sapiens (human) : LIG3 (DNA ligase 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lig3 (DNA ligase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lig3 (DNA ligase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : LIG3 (DNA ligase 3)
Canis lupus familiaris (dog) : LIG3 (DNA ligase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lig3 (DNA ligase 3)
Sus scrofa (pig) : LIG3 (DNA ligase 3)
Chlorocebus sabaeus (African green monkey) : LIG3 (DNA ligase 3)
Heterocephalus glaber (naked mole-rat) : Lig3 (DNA ligase 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391182,671,935 - 82,695,100 (+)NCBI
GRCm381182,781,109 - 82,804,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,781,108 - 82,804,274 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,594,637 - 82,617,776 (+)NCBIGRCm37mm9NCBIm37
MGSCv361182,597,330 - 82,620,469 (+)NCBImm8
Celera1192,400,612 - 92,423,646 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lig3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320453
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.