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Gene: Lig3 (ligase III, DNA, ATP-dependent) Mus musculus
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Symbol: Lig3
Name: ligase III, DNA, ATP-dependent
CRRD ID: 1320453
Description: Predicted to have DNA ligase (ATP) activity. Involved in double-strand break repair via alternative nonhomologous end joining; mitochondrial DNA repair; and negative regulation of DNA recombination. Localizes to synaptonemal complex. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human LIG3 (DNA ligase 3); PARTICIPATES IN nucleotide excision repair pathway; base excision repair pathway; INTERACTS WITH 17alpha-ethynylestradiol; 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D11Wsu78; D11Wsu78e; DNA ligase (ATP) 3; DNA ligase 3; DNA ligase III; MGC78176; polydeoxyribonucleotide synthase [ATP] 3
Orthologs:
Homo sapiens (human) : LIG3 (DNA ligase 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lig3 (DNA ligase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lig3 (DNA ligase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : LIG3 (DNA ligase 3)
Canis lupus familiaris (dog) : LIG3 (DNA ligase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lig3 (DNA ligase 3)
Sus scrofa (pig) : LIG3 (DNA ligase 3)
Chlorocebus sabaeus (African green monkey) : LIG3 (DNA ligase 3)
Heterocephalus glaber (naked mole-rat) : Lig3 (DNA ligase 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,671,935 - 82,695,100 (+)NCBI
GRCm381182,781,109 - 82,804,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,781,108 - 82,804,274 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,594,637 - 82,617,776 (+)NCBIGRCm37mm9NCBIm37
MGSCv361182,597,330 - 82,620,469 (+)NCBImm8
Celera1192,400,612 - 92,423,646 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Lig3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320453
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.