Symbol:
RAB6A
Name:
RAB6A, member RAS oncogene family
Description:
Exhibits several functions, including GTP binding activity; GTPase activity; and myosin V binding activity. Involved in several processes, including Golgi vesicle transport; peptidyl-cysteine methylation; and protein localization to Golgi apparatus. Localizes to the Golgi apparatus; cytosol; and endosome to plasma membrane transport vesicle.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
GTP-binding protein RAB6A'; GTP-binding protein RAB6B; Oncogene RAB6; Rab GTPase; rab-6; RAB6; RAB6, member RAS oncogene family; Rab6A variant 3; RAB6A'; RAB6B; ras-related protein Rab-6A
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Rab6a (RAB6A, member RAS oncogene family) HGNC
Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Rab6a (RAB6A, member RAS oncogene family) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Chinchilla lanigera (long-tailed chinchilla):
Rab6a (RAB6A, member RAS oncogene family) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
RAB6A (RAB6A, member RAS oncogene family) NCBI
Ortholog
Canis lupus familiaris (dog):
RAB6A (RAB6A, member RAS oncogene family) HGNC
EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Rab6a (RAB6A, member RAS oncogene family) NCBI
Ortholog
Sus scrofa (pig):
RAB6A (RAB6A, member RAS oncogene family) HGNC
Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Other homologs 2
Mus musculus (house mouse):
Rab6b (RAB6B, member RAS oncogene family) HGNC
EggNOG, OrthoDB
Rattus norvegicus (Norway rat):
Rab26 (RAB26, member RAS oncogene family) HGNC
Panther
Mus musculus (house mouse):
Rab26 (RAB26, member RAS oncogene family) HGNC
Panther
Rattus norvegicus (Norway rat):
Rab33b (RAB33B, member RAS oncogene family) HGNC
Panther
Mus musculus (house mouse):
Rab37 (RAB37, member RAS oncogene family) HGNC
Panther
Mus musculus (house mouse):
Rab33b (RAB33B, member RAS oncogene family) HGNC
Panther
Mus musculus (house mouse):
Rab33a (RAB33A, member RAS oncogene family) HGNC
Panther
Rattus norvegicus (Norway rat):
Rab33a (RAB33A, member RAS oncogene family) HGNC
Panther
Rattus norvegicus (Norway rat):
Rab37 (RAB37, member RAS oncogene family) HGNC
Panther
Canis lupus familiaris (dog):
RAB26 (RAB26, member RAS oncogene family) HGNC
Panther
Canis lupus familiaris (dog):
RAB6B (RAB6B, member RAS oncogene family) HGNC
OrthoDB
Canis lupus familiaris (dog):
RAB33B (RAB33B, member RAS oncogene family) HGNC
Panther
Canis lupus familiaris (dog):
RAB37 (RAB37, member RAS oncogene family) HGNC
Panther
Canis lupus familiaris (dog):
RAB33A (RAB33A, member RAS oncogene family) HGNC
Panther
Sus scrofa (pig):
RAB33B (RAB33B, member RAS oncogene family) HGNC
Panther
Sus scrofa (pig):
RAB37 (RAB37, member RAS oncogene family) HGNC
Panther
Sus scrofa (pig):
RAB6B (RAB6B, member RAS oncogene family) HGNC
OrthoDB
Sus scrofa (pig):
RAB33A (RAB33A, member RAS oncogene family) HGNC
Panther
Sus scrofa (pig):
RAB26 (RAB26, member RAS oncogene family) HGNC
Panther
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Rab6a (RAB6A, member RAS oncogene family)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Rab6a (RAB6A, member RAS oncogene family)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
rab6a (RAB6A, member RAS oncogene family)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, Roundup, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
Rab6
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
YPT6
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
rab-6.2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 11 73,675,638 - 73,761,074 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 11 73,386,683 - 73,472,201 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 11 73,064,331 - 73,149,849 (-) NCBI NCBI36 hg18 NCBI36 Build 34 11 73,064,332 - 73,149,849 NCBI Celera 11 70,692,067 - 70,777,822 (-) NCBI Cytogenetic Map 11 q13.4 NCBI HuRef 11 69,682,483 - 69,767,815 (-) NCBI HuRef CHM1_1 11 73,270,356 - 73,355,857 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(+)-schisandrin B multiple interactions ISO RGD:619737 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RAB6A mRNA] CTD PMID:31150632 (-)-epigallocatechin 3-gallate increases expression EXP 6480464 epigallocatechin gallate results in increased expression of RAB6A protein CTD PMID:31195006 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of RAB6A mRNA CTD PMID:12588870 17alpha-ethynylestradiol increases expression ISO RGD:1320485 6480464 Ethinyl Estradiol results in increased expression of RAB6A mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1320485 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAB6A mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1320485 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAB6A mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1320485 6480464 Tetrachlorodibenzodioxin affects the expression of RAB6 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1320485 6480464 Tetrachlorodibenzodioxin results in increased expression of RAB6A mRNA CTD PMID:17942748 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RAB6A mRNA CTD PMID:28628672 3H-1,2-dithiole-3-thione decreases expression ISO RGD:619737 6480464 1, 2-dithiol-3-thione results in decreased expression of RAB6A mRNA CTD PMID:19162173 6-propyl-2-thiouracil decreases expression ISO RGD:619737 6480464 Propylthiouracil results in decreased expression of RAB6A mRNA CTD PMID:24780913 all-trans-retinoic acid multiple interactions EXP 6480464 [Tretinoin co-treated with Ascorbic Acid] results in decreased expression of RAB6A mRNA CTD PMID:16443354 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of RAB6A mRNA CTD PMID:15498508 ammonium chloride affects expression ISO RGD:619737 6480464 Ammonium Chloride affects the expression of RAB6A mRNA CTD PMID:16483693 Aroclor 1254 decreases expression ISO RGD:1320485 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of RAB6 mRNA CTD PMID:23650126 benzo[a]pyrene increases expression ISO RGD:1320485 6480464 Benzo(a)pyrene results in increased expression of RAB6 mRNA CTD PMID:22228805 benzo[e]pyrene decreases methylation EXP 6480464 benzo(e)pyrene results in decreased methylation of RAB6A intron CTD PMID:30157460 bisphenol A affects expression ISO RGD:619737 6480464 bisphenol A affects the expression of RAB6A mRNA CTD PMID:25181051 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of RAB6A mRNA CTD PMID:30903817 bisphenol F multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RAB6A mRNA CTD PMID:28628672 clofibric acid multiple interactions ISO RGD:619737 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RAB6A mRNA CTD PMID:17602206 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of RAB6A mRNA CTD PMID:19376846 copper(II) sulfate increases expression EXP 6480464 Copper Sulfate results in increased expression of RAB6A mRNA CTD PMID:19549813 coumestrol decreases expression EXP 6480464 Coumestrol results in decreased expression of RAB6A mRNA CTD PMID:19167446 dexamethasone multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RAB6A mRNA CTD PMID:28628672 dibenzo[a,l]pyrene increases expression EXP 6480464 dibenzo(a, l)pyrene results in increased expression of RAB6A mRNA CTD PMID:15735009 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAB6A mRNA CTD PMID:27188386 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of RAB6A mRNA CTD PMID:29803840 ethanol multiple interactions ISO RGD:1320485 6480464 Ethanol affects the expression of and affects the splicing of RAB6A mRNA CTD PMID:30319688 flutamide increases expression ISO RGD:619737 6480464 Flutamide results in increased expression of RAB6A mRNA CTD PMID:24136188 gentamycin decreases expression ISO RGD:619737 6480464 Gentamicins results in decreased expression of RAB6 mRNA, Gentamicins results in decreased expression of RAB6A mRNA CTD PMID:22061828 haloperidol increases expression ISO RGD:619737 6480464 Haloperidol results in increased expression of RAB6A mRNA CTD PMID:15860345 hydralazine multiple interactions EXP 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of RAB6A mRNA CTD PMID:17183730 indoles increases expression ISO RGD:619737 6480464 Indoles results in increased expression of RAB6A mRNA CTD PMID:20521778 indoles decreases expression ISO RGD:619737 6480464 Indoles results in decreased expression of RAB6A mRNA CTD PMID:20521778 indometacin multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RAB6A mRNA CTD PMID:28628672 L-ascorbic acid multiple interactions EXP 6480464 [Tretinoin co-treated with Ascorbic Acid] results in decreased expression of RAB6A mRNA CTD PMID:16443354 lead(0) affects expression EXP 6480464 Lead affects the expression of RAB6A mRNA CTD PMID:28903495 lead(2+) affects expression EXP 6480464 Lead affects the expression of RAB6A mRNA CTD PMID:28903495 megestrol acetate increases expression EXP 6480464 Megestrol Acetate results in increased expression of RAB6A protein CTD PMID:16939895 methapyrilene decreases methylation EXP 6480464 Methapyrilene results in decreased methylation of RAB6A intron CTD PMID:30157460 methapyrilene decreases expression ISO RGD:619737 6480464 Methapyrilene results in decreased expression of RAB6A mRNA CTD PMID:30467583 methoxychlor increases methylation ISO RGD:619737 6480464 Methoxychlor results in increased methylation of RAB6A gene CTD PMID:23303685 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of RAB6A mRNA CTD PMID:28001369 N-nitrosodiethylamine multiple interactions ISO RGD:619737 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RAB6A mRNA CTD PMID:17602206 nefazodone increases expression ISO RGD:619737 6480464 nefazodone results in increased expression of RAB6A mRNA CTD PMID:24136188 nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of RAB6A mRNA CTD PMID:12588870 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of RAB6A mRNA CTD PMID:22230336 perfluorooctanoic acid increases expression ISO RGD:619737 6480464 perfluorooctanoic acid results in increased expression of RAB6A mRNA CTD PMID:19162173 phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of RAB6A mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAB6A mRNA CTD PMID:27188386 Propiverine affects binding ISO RGD:619737 6480464 propiverine binds to RAB6A protein CTD PMID:29273565 resveratrol increases expression ISO RGD:1320485 6480464 resveratrol results in increased expression of RAB6A protein CTD PMID:25505154 Risedronate sodium decreases prenylation EXP 6480464 Risedronic Acid results in decreased prenylation of RAB6A protein CTD PMID:16619218 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAB6A mRNA CTD PMID:27188386 sodium fluoride decreases expression ISO RGD:1320485 6480464 Sodium Fluoride results in decreased expression of RAB6A protein CTD PMID:28918527 succimer multiple interactions EXP 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of RAB6A mRNA CTD PMID:26378955 tamibarotene affects expression EXP 6480464 tamibarotene affects the expression of RAB6A mRNA CTD PMID:15498508 tetrachloromethane increases expression ISO RGD:1320485 6480464 Carbon Tetrachloride results in increased expression of RAB6A mRNA CTD PMID:27339419 tetrachloromethane increases expression ISO RGD:619737 6480464 Carbon Tetrachloride results in increased expression of RAB6A mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO RGD:619737 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RAB6A mRNA] CTD PMID:31150632 trichloroethene increases expression ISO RGD:1320485 6480464 Trichloroethylene results in increased expression of RAB6 mRNA CTD PMID:19448997 ursodeoxycholic acid increases expression ISO RGD:619737 6480464 Ursodeoxycholic Acid results in increased expression of RAB6A mRNA CTD PMID:15885361 valproic acid multiple interactions EXP 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of RAB6A mRNA CTD PMID:17183730 valproic acid affects expression ISO RGD:1320485 6480464 Valproic Acid affects the expression of RAB6A mRNA CTD PMID:17292431 vinclozolin affects expression ISO RGD:619737 6480464 vinclozolin affects the expression of RAB6A mRNA CTD PMID:19015723 vorinostat decreases expression EXP 6480464 vorinostat results in decreased expression of RAB6A mRNA CTD PMID:27188386 zoledronic acid increases expression EXP 6480464 zoledronic acid results in increased expression of RAB6A mRNA CTD PMID:20977926 
Gene Ontology Annotations
