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Gene: HLCS (holocarboxylase synthetase) Homo sapiens
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Symbol: HLCS
Name: holocarboxylase synthetase
Description: Exhibits biotin binding activity; biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity; and enzyme binding activity. Involved in cell population proliferation; histone biotinylation; and response to biotin. Localizes to the chromatin; cytosol; and nuclear periphery. Implicated in holocarboxylase synthetase deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: biotin apo-protein ligase; biotin--[acetyl-CoA-carboxylase] ligase; biotin--[methylcrotonoyl-CoA-carboxylase] ligase; biotin--[methylmalonyl-CoA-carboxytransferase] ligase; biotin--protein ligase; HCS; holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)
Orthologs:
Mus musculus (house mouse) : Hlcs (holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase))  MGI  Alliance
Rattus norvegicus (Norway rat) : Hlcs (holocarboxylase synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hlcs (holocarboxylase synthetase)
Pan paniscus (bonobo/pygmy chimpanzee) : HLCS (holocarboxylase synthetase)
Canis lupus familiaris (dog) : HLCS (holocarboxylase synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hlcs (holocarboxylase synthetase)
Sus scrofa (pig) : HLCS (holocarboxylase synthetase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382136,748,625 - 36,990,255 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372138,123,189 - 38,362,545 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,045,059 - 37,284,373 (-)NCBINCBI36hg18NCBI36
Build 342137,045,058 - 37,284,373NCBI
Celera2123,321,570 - 23,560,921 (-)NCBI
Cytogenetic Map21q22.13ENTREZGENE
HuRef2123,599,006 - 23,838,349 (-)NCBIHuRef
CHM1_12137,684,363 - 37,923,921 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on HLCS
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320489
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.