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Gene: ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase) Homo sapiens
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Symbol: ALG2
Name: ALG2 alpha-1,3/1,6-mannosyltransferase
Description: Exhibits several functions, including alpha-1,3-mannosyltransferase activity; calcium-dependent protein binding activity; and protein heterodimerization activity. Involved in dolichol-linked oligosaccharide biosynthetic process; protein glycosylation in endoplasmic reticulum; and response to calcium ion. Localizes to several cellular components, including the actin cytoskeleton; cytosol; and perinuclear region of cytoplasm. Implicated in congenital disorder of glycosylation Ii and congenital myasthenic syndrome 14.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALG2, alpha-1,3/1,6-mannosyltransferase; alpha-1,3-mannosyltransferase ALG2; alpha-1,3/1,6-mannosyltransferase ALG2; asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog; asparagine-linked glycosylation protein 2 homolog; CDG1I; CDGIi; CMS14; CMSTA3; FLJ14511; GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase; GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; hALPG2; homolog of yeast ALG2; NET38
Orthologs:
Mus musculus (house mouse) : Alg2 (asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase))  MGI  Alliance
Rattus norvegicus (Norway rat) : Alg2 (ALG2, alpha-1,3/1,6-mannosyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alg2 (ALG2 alpha-1,3/1,6-mannosyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase)
Canis lupus familiaris (dog) : ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alg2 (ALG2 alpha-1,3/1,6-mannosyltransferase)
Sus scrofa (pig) : ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: ALG2 (Gene ID: 85365) and PDCD6 (Gene ID: 10016) share the ALG2 symbol/alias in common. ALG2 is a widely used alternative name for programmed cell death 6 (PDCD6), whose synonym is apoptosis-linked gene-2. This can be confused with the official symbol for ALG2, alpha-1,3/1,6-mannosyltransferase (ALG2). [31 May 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38999,216,425 - 99,221,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379101,978,707 - 101,984,246 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369101,018,528 - 101,024,067 (-)NCBINCBI36hg18NCBI36
Celera972,492,570 - 72,498,109 (-)NCBI
Cytogenetic Map9q22.33NCBI
HuRef971,577,356 - 71,582,895 (-)NCBIHuRef
CHM1_19102,125,156 - 102,130,695 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Sequence

Nucleotide Sequences
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Additional Information

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Nomenclature History
 
More on ALG2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320554
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.