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Gene: GSTA4 (glutathione S-transferase alpha 4) Homo sapiens
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Symbol: GSTA4
Name: glutathione S-transferase alpha 4
Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686D21185; glutathione S-alkyltransferase A4; glutathione S-aralkyltransferase A4; glutathione S-aryltransferase A4; glutathione S-transferase A4; glutathione S-transferase A4-4; glutathione transferase A4-4; GST class-alpha member 4; GSTA4-4; GTA4; S-(hydroxyalkyl)glutathione lyase A4
Orthologs:
Mus musculus (house mouse) : Gm10639 (predicted gene 10639)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gsta4 (glutathione S-transferase alpha 4)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : GSTA4 (glutathione S-transferase alpha 4)
Canis lupus familiaris (dog) : GSTA4 (glutathione S-transferase alpha 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gsta4 (glutathione S-transferase alpha 4)
Sus scrofa (pig) : GSTA4 (glutathione S-transferase alpha 4)
more info ...
Related Pseudogenes: GSTA9P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,977,952 - 52,995,332 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37652,842,746 - 52,860,178 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,950,710 - 52,968,099 (-)NCBINCBI36hg18NCBI36
Build 34652,950,709 - 52,968,099NCBI
Celera654,504,520 - 54,521,952 (-)NCBI
Cytogenetic Map6p12.2NCBI
HuRef652,674,221 - 52,691,656 (-)NCBIHuRef
CHM1_1652,844,511 - 52,861,941 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on GSTA4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320601
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.