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Gene: Cr2 (complement receptor 2) Mus musculus
Symbol: Cr2
Name: complement receptor 2
Description: Exhibits complement receptor activity. Involved in several processes, including cellular response to lipopolysaccharide; complement activation, alternative pathway; and skeletal system development. Localizes to external side of plasma membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2); PARTICIPATES IN B cell receptor signaling pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C3DR; CD21; CD35; complement C3d receptor; complement receptor type 1; complement receptor type 2; Cr-1; Cr-2; Cr1; expressed in B lymphocytes; MGC130295
Homo sapiens (human) : CR2 (complement C3d receptor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cr2 (complement C3d receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cr2 (complement C3d receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CR2 (complement C3d receptor 2)
Canis lupus familiaris (dog) : CR2 (complement C3d receptor 2)
Chlorocebus sabaeus (African green monkey) : CR2 (complement C3d receptor 2)
Heterocephalus glaber (naked mole-rat) : Cr2 (complement C3d receptor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1195,136,811 - 195,176,716 (-)EnsemblGRCm38mm10GRCm38
GRCm381195,136,811 - 195,176,880 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371196,963,005 - 197,002,909 (-)NCBIGRCm37mm9NCBIm37
MGSCv361196,840,394 - 196,877,439 (-)NCBImm8
Celera1202,035,969 - 202,075,750 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map198.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cr2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320754
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.