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Gene: Pycr2 (pyrroline-5-carboxylate reductase family, member 2) Mus musculus
Symbol: Pycr2
Name: pyrroline-5-carboxylate reductase family, member 2
Description: Predicted to have pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process and cellular response to oxidative stress. Predicted to localize to the mitochondrion. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 10. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and skeleton. Orthologous to human PYCR2 (pyrroline-5-carboxylate reductase 2); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1810018M05Rik; Leftb; P5C reductase 2; P5CR 2; P5cr2; pyrroline-5-carboxylate reductase 2
Homo sapiens (human) : PYCR2 (pyrroline-5-carboxylate reductase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pycr2 (pyrroline-5-carboxylate reductase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pycr2 (pyrroline-5-carboxylate reductase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PYCR2 (pyrroline-5-carboxylate reductase 2)
Canis lupus familiaris (dog) : PYCR2 (pyrroline-5-carboxylate reductase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pycr2 (pyrroline-5-carboxylate reductase 2)
Sus scrofa (pig) : PYCR2 (pyrroline-5-carboxylate reductase 2)
Chlorocebus sabaeus (African green monkey) : PYCR2 (pyrroline-5-carboxylate reductase 2)
Heterocephalus glaber (naked mole-rat) : Pycr2 (pyrroline-5-carboxylate reductase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1180,904,293 - 180,908,088 (+)EnsemblGRCm38mm10GRCm38
GRCm381180,904,274 - 180,908,088 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371182,834,405 - 182,838,219 (+)NCBIGRCm37mm9NCBIm37
MGSCv361182,740,984 - 182,744,763 (+)NCBImm8
Celera1187,967,388 - 187,971,204 (+)NCBICelera
Cytogenetic Map1H4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pycr2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320769
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.