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Gene: SARM1 (sterile alpha and TIR motif containing 1) Homo sapiens
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Symbol: SARM1
Name: sterile alpha and TIR motif containing 1
Description: Exhibits NAD+ nucleotidase, cyclic ADP-ribose generating and identical protein binding activity. Involved in NAD catabolic process; positive regulation of neuron death; and response to axon injury. Localizes to mitochondrion; INTERACTS WITH 2-methylcholine; arsenous acid; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ36296; hSARM1; HsTIR; KIAA0524; MyD88-5; NAD(+) hydrolase SARM1; NADase SARM1; NADP(+) hydrolase SARM1; SAM domain-containing protein 2; SAMD2; SARM; sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif-containing protein 1; sterile alpha motif domain-containing protein 2; tir-1 homolog
Orthologs:
Mus musculus (house mouse) : Sarm1 (sterile alpha and HEAT/Armadillo motif containing 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sarm1 (sterile alpha and TIR motif containing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sarm1 (sterile alpha and TIR motif containing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SARM1 (sterile alpha and TIR motif containing 1)
Canis lupus familiaris (dog) : SARM1 (sterile alpha and TIR motif containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sarm1 (sterile alpha and TIR motif containing 1)
Sus scrofa (pig) : SARM1 (sterile alpha and TIR motif containing 1)
Chlorocebus sabaeus (African green monkey) : SARM1 (sterile alpha and TIR motif containing 1)
Heterocephalus glaber (naked mole-rat) : Sarm1 (sterile alpha and TIR motif containing 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1728,364,356 - 28,404,049 (+)EnsemblGRCh38hg38GRCh38
GRCh381728,371,694 - 28,404,049 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371726,698,683 - 26,728,062 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,723,114 - 23,752,192 (+)NCBINCBI36hg18NCBI36
Build 341723,723,252 - 23,752,192NCBI
Celera1723,560,746 - 23,589,829 (+)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1722,907,093 - 22,936,406 (+)NCBIHuRef
CHM1_11726,761,617 - 26,790,977 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - uncurated

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Comparative Map Data
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miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on SARM1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320776
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.