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Gene: Dhx58 (DEXH (Asp-Glu-X-His) box polypeptide 58) Mus musculus
Symbol: Dhx58
Name: DEXH (Asp-Glu-X-His) box polypeptide 58
Description: Exhibits double-stranded RNA binding activity. Involved in several processes, including negative regulation of innate immune response; regulation of cytokine production; and response to virus. Localizes to cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DHX58 (DExH-box helicase 58); PARTICIPATES IN Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B430001I08Rik; D11Lgp2e; dna segment, chr 11, lothar hennighausen 2, expressed; Lgp2; LPG2; probable ATP-dependent helicase LGP2; probable ATP-dependent RNA helicase DHX58; protein D11Lgp2; RIG-I-like receptor 3; RIG-I-like receptor Lgp2; RLR; RLR-3; RNA helicase LGP2; RP23-390D17.5
Homo sapiens (human) : DHX58 (DExH-box helicase 58)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dhx58 (DEXH-box helicase 58)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhx58 (DExH-box helicase 58)
Pan paniscus (bonobo/pygmy chimpanzee) : DHX58 (DExH-box helicase 58)
Canis lupus familiaris (dog) : DHX58 (DExH-box helicase 58)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhx58 (DExH-box helicase 58)
Sus scrofa (pig) : DHX58 (DExH-box helicase 58)
Chlorocebus sabaeus (African green monkey) : DHX58 (DExH-box helicase 58)
Heterocephalus glaber (naked mole-rat) : Dhx58 (DExH-box helicase 58)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl11100,694,884 - 100,704,271 (-)EnsemblGRCm38mm10GRCm38
GRCm3811100,694,884 - 100,704,271 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711100,556,198 - 100,565,585 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611100,510,974 - 100,520,361 (-)NCBImm8
Celera11111,311,383 - 111,320,770 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dhx58
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320800
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.