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Gene: Dhx58 (DEXH (Asp-Glu-X-His) box polypeptide 58) Mus musculus
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Symbol: Dhx58
Name: DEXH (Asp-Glu-X-His) box polypeptide 58
Description: Exhibits double-stranded RNA binding activity. Involved in several processes, including negative regulation of innate immune response; regulation of cytokine production; and response to virus. Localizes to cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DHX58 (DExH-box helicase 58); PARTICIPATES IN Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B430001I08Rik; D11Lgp2e; dna segment, chr 11, lothar hennighausen 2, expressed; Lgp2; LPG2; probable ATP-dependent helicase LGP2; probable ATP-dependent RNA helicase DHX58; protein D11Lgp2; RIG-I-like receptor 3; RIG-I-like receptor Lgp2; RLR; RLR-3; RNA helicase LGP2; RP23-390D17.5
Orthologs:
Homo sapiens (human) : DHX58 (DExH-box helicase 58)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dhx58 (DEXH-box helicase 58)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhx58 (DExH-box helicase 58)
Pan paniscus (bonobo/pygmy chimpanzee) : DHX58 (DExH-box helicase 58)
Canis lupus familiaris (dog) : DHX58 (DExH-box helicase 58)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhx58 (DExH-box helicase 58)
Sus scrofa (pig) : DHX58 (DExH-box helicase 58)
Chlorocebus sabaeus (African green monkey) : DHX58 (DExH-box helicase 58)
Heterocephalus glaber (naked mole-rat) : Dhx58 (DExH-box helicase 58)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl11100,694,884 - 100,704,271 (-)EnsemblGRCm38mm10GRCm38
GRCm3811100,694,884 - 100,704,271 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711100,556,198 - 100,565,585 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611100,510,974 - 100,520,361 (-)NCBImm8
Celera11111,311,383 - 111,320,770 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dhx58
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320800
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.