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Gene: JCHAIN (joining chain of multimeric IgA and IgM) Homo sapiens
Symbol: JCHAIN
Name: joining chain of multimeric IgA and IgM
Description: Exhibits IgA binding activity and protein homodimerization activity. Contributes to several functions, including immunoglobulin receptor binding activity; peptidoglycan binding activity; and phosphatidylcholine binding activity. Involved in several processes, including defense response to other organism; glomerular filtration; and positive regulation of protein oligomerization. Localizes to the monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory dimeric IgA immunoglobulin complex; INTERACTS WITH (-)-demecolcine; arsenite(3-); butanal.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IGCJ; IGJ; IgJ chain; immunoglobulin J chain; immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides; J chain; JCH
Mus musculus (house mouse) : Jchain (immunoglobulin joining chain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Jchain (joining chain of multimeric IgA and IgM)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jchain (joining chain of multimeric IgA and IgM)
Pan paniscus (bonobo/pygmy chimpanzee) : JCHAIN (joining chain of multimeric IgA and IgM)
Canis lupus familiaris (dog) : JCHAIN (joining chain of multimeric IgA and IgM)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jchain (joining chain of multimeric IgA and IgM)
Sus scrofa (pig) : JCHAIN (joining chain of multimeric IgA and IgM)
more info ...
Related Pseudogenes: JCHAINP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38470,655,541 - 70,666,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37471,521,258 - 71,532,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36471,740,548 - 71,751,128 (-)NCBINCBI36hg18NCBI36
Build 34471,886,718 - 71,897,299NCBI
Celera468,878,257 - 68,889,347 (-)NCBI
Cytogenetic Map4q13.3NCBI
HuRef467,325,225 - 67,336,298 (-)NCBIHuRef
CHM1_1471,557,251 - 71,568,341 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on JCHAIN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320892
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.