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Gene: JCHAIN (joining chain of multimeric IgA and IgM) Homo sapiens
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Symbol: JCHAIN
Name: joining chain of multimeric IgA and IgM
Description: Exhibits IgA binding activity and protein homodimerization activity. Contributes to several functions, including immunoglobulin receptor binding activity; peptidoglycan binding activity; and phosphatidylcholine binding activity. Involved in several processes, including defense response to other organism; glomerular filtration; and positive regulation of protein oligomerization. Localizes to the monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory dimeric IgA immunoglobulin complex; INTERACTS WITH (-)-demecolcine; arsenite(3-); butanal.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IGCJ; IGJ; IgJ chain; immunoglobulin J chain; immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides; J chain; JCH
Orthologs:
Mus musculus (house mouse) : Jchain (immunoglobulin joining chain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Jchain (joining chain of multimeric IgA and IgM)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jchain (joining chain of multimeric IgA and IgM)
Pan paniscus (bonobo/pygmy chimpanzee) : JCHAIN (joining chain of multimeric IgA and IgM)
Canis lupus familiaris (dog) : JCHAIN (joining chain of multimeric IgA and IgM)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jchain (joining chain of multimeric IgA and IgM)
Sus scrofa (pig) : JCHAIN (joining chain of multimeric IgA and IgM)
more info ...
Related Pseudogenes: JCHAINP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38470,655,541 - 70,666,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37471,521,258 - 71,532,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36471,740,548 - 71,751,128 (-)NCBINCBI36hg18NCBI36
Build 34471,886,718 - 71,897,299NCBI
Celera468,878,257 - 68,889,347 (-)NCBI
Cytogenetic Map4q13.3NCBI
HuRef467,325,225 - 67,336,298 (-)NCBIHuRef
CHM1_1471,557,251 - 71,568,341 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on JCHAIN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320892
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.