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Gene: DDB2 (damage specific DNA binding protein 2) Homo sapiens
Symbol: DDB2
Name: damage specific DNA binding protein 2
Description: Contributes to damaged DNA binding activity and ubiquitin-protein transferase activity. Involved in UV-damage excision repair and protein ubiquitination. Localizes to the Cul4B-RING E3 ubiquitin ligase complex; cell junction; and nucleoplasm. Implicated in xeroderma pigmentosum and xeroderma pigmentosum group E.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: damage-specific DNA binding protein 2, 48kDa; damage-specific DNA-binding protein 2; DDB p48 subunit; DDBB; DNA damage-binding protein 2; FLJ34321; UV-damaged DNA-binding protein 2; UV-DDB 2; UV-DDB2; xeroderma pigmentosum group E protein; XPE
Mus musculus (house mouse) : Ddb2 (damage specific DNA binding protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddb2 (damage specific DNA binding protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddb2 (damage specific DNA binding protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DDB2 (damage specific DNA binding protein 2)
Canis lupus familiaris (dog) : DDB2 (damage specific DNA binding protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddb2 (damage specific DNA binding protein 2)
Sus scrofa (pig) : DDB2 (damage specific DNA binding protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1147,214,465 - 47,239,240 (+)Ensembl
GRCh381147,214,942 - 47,239,218 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371147,236,493 - 47,260,769 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,193,089 - 47,217,339 (+)NCBINCBI36hg18NCBI36
Build 341147,193,088 - 47,217,339NCBI
Celera1147,375,719 - 47,399,996 (+)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1146,935,465 - 46,959,749 (+)NCBIHuRef
CHM1_11147,235,200 - 47,259,461 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DDB2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320906
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.