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Gene: Alx4 (aristaless-like homeobox 4) Mus musculus
Symbol: Alx4
Name: aristaless-like homeobox 4
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and protein heterodimerization activity. Involved in several processes, including embryonic limb morphogenesis; embryonic skeletal system morphogenesis; and roof of mouth development. Localizes to the nucleus and transcription factor complex. Used to study parietal foramina. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human ALX4 (ALX homeobox 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bis(2-chloroethyl) sulfide; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ALX-4; aristaless 4; Aristaless-like 4; homeobox protein aristaless-like 4; lst; Strong's luxoid
Homo sapiens (human) : ALX4 (ALX homeobox 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Alx4 (ALX homeobox 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alx4 (ALX homeobox 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ALX4 (ALX homeobox 4)
Canis lupus familiaris (dog) : ALX4 (ALX homeobox 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alx4 (ALX homeobox 4)
Sus scrofa (pig) : ALX4 (ALX homeobox 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38293,642,434 - 93,681,341 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37293,482,591 - 93,521,496 (+)NCBIGRCm37mm9NCBIm37
MGSCv36293,443,273 - 93,478,775 (+)NCBImm8
Celera295,046,101 - 95,085,009 (+)NCBICelera
Cytogenetic Map2 E1NCBI
cM Map251.62NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Alx4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1320964
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.