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Gene: USP22 (ubiquitin specific peptidase 22) Homo sapiens
Symbol: USP22
Name: ubiquitin specific peptidase 22
Description: Exhibits enzyme binding activity; nuclear receptor transcription coactivator activity; and thiol-dependent ubiquitin-specific protease activity. Contributes to H4 histone acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Localizes to SAGA complex. Colocalizes with SAGA-type complex; PARTICIPATES IN histone modification pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH dicrotophos; methotrexate; pinosylvin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: deubiquitinating enzyme 22; KIAA1063; ubiquitin carboxyl-terminal hydrolase 22; ubiquitin specific peptidase 3-like; ubiquitin specific protease 22; ubiquitin specific protease 3-like; ubiquitin thioesterase 22; ubiquitin thiolesterase 22; ubiquitin-specific processing protease 22; ubiquitin-specific-processing protease 22; USP3L
Mus musculus (house mouse) : Usp22 (ubiquitin specific peptidase 22)  MGI  Alliance
Rattus norvegicus (Norway rat) : Usp22 (ubiquitin specific peptidase 22)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp22 (ubiquitin specific peptidase 22)
Pan paniscus (bonobo/pygmy chimpanzee) : USP22 (ubiquitin specific peptidase 22)
Canis lupus familiaris (dog) : USP22 (ubiquitin specific peptidase 22)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp22 (ubiquitin specific peptidase 22)
Sus scrofa (pig) : USP22 (ubiquitin specific peptidase 22)
Chlorocebus sabaeus (African green monkey) : USP22 (ubiquitin specific peptidase 22)
Heterocephalus glaber (naked mole-rat) : Usp22 (ubiquitin specific peptidase 22)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1720,999,596 - 21,043,760 (-)EnsemblGRCh38hg38GRCh38
GRCh381720,999,596 - 21,043,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371720,902,906 - 20,946,722 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361720,843,498 - 20,886,944 (-)NCBINCBI36hg18NCBI36
Build 341720,843,501 - 20,886,944NCBI
Celera1721,596,363 - 21,639,730 (+)NCBI
Cytogenetic Map17p11.2NCBI
HuRef1720,105,104 - 20,134,191 (-)NCBIHuRef
CHM1_11720,912,612 - 20,956,003 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on USP22
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1321210
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.