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Gene: Topbp1 (topoisomerase (DNA) II binding protein 1) Mus musculus
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Symbol: Topbp1
Name: topoisomerase (DNA) II binding protein 1
Description: Predicted to have identical protein binding activity. Predicted to be involved in DNA metabolic process; mitotic G2/M transition checkpoint; and response to ionizing radiation. Localizes to condensed nuclear chromosome and male germ cell nucleus. Is expressed in embryo and metanephros. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1); INTERACTS WITH (+)-dexrazoxane; 1,1-dichloroethene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1110031N14Rik; 2810429C13Rik; AI256758; D430026L04Rik; DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; mKIAA0259; topoisomerase (DNA) II beta binding protein
Orthologs:
Homo sapiens (human) : TOPBP1 (DNA topoisomerase II binding protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Topbp1 (DNA topoisomerase II binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Topbp1 (DNA topoisomerase II binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TOPBP1 (DNA topoisomerase II binding protein 1)
Canis lupus familiaris (dog) : TOPBP1 (DNA topoisomerase II binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Topbp1 (DNA topoisomerase II binding protein 1)
Sus scrofa (pig) : TOPBP1 (DNA topoisomerase II binding protein 1)
Chlorocebus sabaeus (African green monkey) : TOPBP1 (DNA topoisomerase II binding protein 1)
Heterocephalus glaber (naked mole-rat) : Topbp1 (DNA topoisomerase II binding protein 1)
more info ...
Related Pseudogenes: Gm18831   Topbp1-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl9103,305,215 - 103,350,428 (+)EnsemblGRCm38mm10GRCm38
GRCm389103,305,167 - 103,350,428 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379103,207,657 - 103,252,758 (+)NCBIGRCm37mm9NCBIm37
MGSCv369103,163,477 - 103,208,578 (+)NCBImm8
Celera9102,854,061 - 102,901,479 (+)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Topbp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1321300
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.