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Gene: TRAF2 (TNF receptor associated factor 2) Homo sapiens
Symbol: TRAF2
Name: TNF receptor associated factor 2
Description: Exhibits several functions, including enzyme binding activity; tumor necrosis factor receptor binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of signal transduction; and protein ubiquitination. Localizes to several cellular components, including the IRE1-TRAF2-ASK1 complex; TRAF2-GSTP1 complex; and ubiquitin ligase complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E3 ubiquitin-protein ligase TRAF2; MGC:45012; RING-type E3 ubiquitin transferase TRAF2; RNF117; TNF receptor-associated factor 2; TRAP; TRAP3; tumor necrosis factor type 2 receptor associated protein 3; tumor necrosis factor type 2 receptor-associated protein 3
Mus musculus (house mouse) : Traf2 (TNF receptor-associated factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Traf2 (Tnf receptor-associated factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Traf2 (TNF receptor associated factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TRAF2 (TNF receptor associated factor 2)
Canis lupus familiaris (dog) : TRAF2 (TNF receptor associated factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Traf2 (TNF receptor associated factor 2)
Sus scrofa (pig) : TRAF2 (TNF receptor associated factor 2)
Chlorocebus sabaeus (African green monkey) : TRAF2 (TNF receptor associated factor 2)
Heterocephalus glaber (naked mole-rat) : Traf2 (TNF receptor associated factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl9136,881,912 - 136,926,607 (+)Ensembl
GRCh389136,881,933 - 136,926,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379139,776,341 - 139,821,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,900,786 - 138,940,888 (+)NCBINCBI36hg18NCBI36
Build 349137,056,801 - 137,096,903NCBI
Celera9110,295,018 - 110,335,296 (+)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9109,252,590 - 109,280,516 (+)NCBIHuRef
CHM1_19139,929,666 - 139,969,783 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TRAF2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1321367
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.