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Gene: CRBN (cereblon) Homo sapiens
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Symbol: CRBN
Name: cereblon
Description: Predicted to have metal ion binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Localizes to the Cul4A-RING E3 ubiquitin ligase complex; cytoplasm; and nucleus. Implicated in autosomal recessive non-syndromic intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp781K0715; mental retardation, non-syndromic, autosomal recessive, 2A; MGC27358; MRT2; MRT2A; protein cereblon; protein x 0001
Orthologs:
Mus musculus (house mouse) : Crbn (cereblon)  MGI  Alliance
Rattus norvegicus (Norway rat) : Crbn (cereblon)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crbn (cereblon)
Pan paniscus (bonobo/pygmy chimpanzee) : CRBN (cereblon)
Canis lupus familiaris (dog) : CRBN (cereblon)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crbn (cereblon)
Sus scrofa (pig) : CRBN (cereblon)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl33,144,628 - 3,179,727 (-)Ensembl
GRCh3833,148,490 - 3,179,717 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3733,191,317 - 3,221,401 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3633,166,695 - 3,196,390 (-)NCBINCBI36hg18NCBI36
Build 3433,166,697 - 3,196,390NCBI
Celera33,130,511 - 3,160,615 (-)NCBI
Cytogenetic Map3p26.2NCBI
HuRef33,125,335 - 3,155,445 (-)NCBIHuRef
CHM1_133,141,344 - 3,171,426 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CRBN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1321492
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.