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Gene: Rbpj (recombination signal binding protein for immunoglobulin kappa J region) Mus musculus
Symbol: Rbpj
Name: recombination signal binding protein for immunoglobulin kappa J region
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein N-terminus binding activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of signal transduction. Localizes to nucleus and transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; neural ectoderm; paraxial mesenchyme; and retina. Used to study aortic valve disease. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI843960; CBF1; Igkjrb; Igkrsbp; j kappa-recombination signal-binding protein; RBP-J; RBP-J kappa; RBP-Jkappa; RBPjk; Rbpsuh; recombining binding protein suppressor of hairless
Related Pseudogenes: Rbpj-ps1   Rbpj-ps2   Rbpj-ps3  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl553,466,152 - 53,657,362 (+)EnsemblGRCm38mm10GRCm38
GRCm38553,555,779 - 53,657,445 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37553,947,018 - 54,048,684 (+)NCBIGRCm37mm9NCBIm37
MGSCv36553,878,593 - 53,944,281 (+)NCBImm8
Celera550,938,216 - 51,041,035 (+)NCBICelera
Cytogenetic Map5C1NCBI
cM Map529.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Rbpj
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1321530
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.