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Gene: NKX2-8 (NK2 homeobox 8) Homo sapiens
Symbol: NKX2-8
Name: NK2 homeobox 8
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Predicted to localize to the nuclear chromatin.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: homeobox protein NK-2 homolog H; homeobox protein Nkx-2.8; NK-2 homolog 8; NK-2 homolog H; NK2 transcription factor related, locus 8; Nkx2-9; NKX2.8; NKX2H
Mus musculus (house mouse) : Nkx2-9 (NK2 homeobox 9)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nkx2-8 (NK2 homeobox 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx2-8 (NK2 homeobox 8)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX2-8 (NK2 homeobox 8)
Canis lupus familiaris (dog) : NKX2-8 (NK2 homeobox 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx2-8 (NK2 homeobox 8)
Sus scrofa (pig) : NKX2-8 (NK2 homeobox 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1436,580,004 - 36,582,614 (-)Ensembl
GRCh381436,580,004 - 36,582,614 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371437,049,216 - 37,051,786 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361436,118,967 - 36,121,537 (-)NCBINCBI36hg18NCBI36
Build 341436,118,967 - 36,121,537NCBI
Celera1416,912,759 - 16,915,329 (-)NCBI
Cytogenetic Map14q13.3NCBI
HuRef1417,163,843 - 17,166,413 (-)NCBIHuRef
CHM1_11437,048,339 - 37,050,942 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NKX2-8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1321643
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.