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Gene: CASS4 (Cas scaffold protein family member 4) Homo sapiens
Symbol: CASS4
Name: Cas scaffold protein family member 4
Description: Exhibits protein tyrosine kinase binding activity. Involved in positive regulation of cell migration; positive regulation of protein tyrosine kinase activity; and positive regulation of substrate adhesion-dependent cell spreading. Localizes to the focal adhesion. Predicted to colocalize with the plasma membrane; INTERACTS WITH aflatoxin B1; benzo[a]pyrene; benzo[e]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C20orf32; cas scaffolding protein family member 4; CAS4; HEF-like protein; HEF1-EFS-p130Cas-like protein; HEFL; HEPL
Mus musculus (house mouse) : Cass4 (Cas scaffolding protein family member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cass4 (Cas scaffold protein family member 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cass4 (Cas scaffold protein family member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : CASS4 (Cas scaffold protein family member 4)
Canis lupus familiaris (dog) : CASS4 (Cas scaffold protein family member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cass4 (Cas scaffold protein family member 4)
Sus scrofa (pig) : CASS4 (Cas scaffold protein family member 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382056,411,550 - 56,460,382 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372054,987,168 - 55,034,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362054,420,771 - 54,467,243 (+)NCBINCBI36hg18NCBI36
Build 342054,420,770 - 54,467,243NCBI
Celera2051,727,599 - 51,774,824 (+)NCBI
Cytogenetic Map20q13.31NCBI
HuRef2051,772,068 - 51,819,214 (+)NCBIHuRef
CHM1_12054,888,283 - 54,935,521 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CASS4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1321668
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.