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Gene: AFAP1L2 (actin filament associated protein 1 like 2) Homo sapiens
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Symbol: AFAP1L2
Name: actin filament associated protein 1 like 2
Description: Exhibits SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Involved in several processes, including inflammatory response; positive regulation of epidermal growth factor receptor signaling pathway; and regulation of gene expression. Localizes to cytosol and plasma membrane; INTERACTS WITH 17beta-estradiol; 2-hydroxypropanoic acid; 4-nonylphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: actin filament associated protein 1-like 2; actin filament-associated protein 1-like 2; AFAP1-like protein 2; CTB-1144G6.4; CTB-1144G6.6; FLJ14564; KIAA1914; XB130
Orthologs:
Mus musculus (house mouse) : Afap1l2 (actin filament associated protein 1-like 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Afap1l2 (actin filament associated protein 1-like 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Afap1l2 (actin filament associated protein 1 like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AFAP1L2 (actin filament associated protein 1 like 2)
Canis lupus familiaris (dog) : AFAP1L2 (actin filament associated protein 1 like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Afap1l2 (actin filament associated protein 1 like 2)
Sus scrofa (pig) : AFAP1L2 (actin filament associated protein 1 like 2)
Heterocephalus glaber (naked mole-rat) : Afap1l2 (actin filament associated protein 1 like 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl10114,294,824 - 114,404,756 (-)EnsemblGRCh38hg38GRCh38
GRCh3810114,280,760 - 114,404,778 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710116,041,248 - 116,164,515 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610116,044,573 - 116,154,505 (-)NCBINCBI36hg18NCBI36
Build 3410116,044,573 - 116,154,505NCBI
Celera10109,783,766 - 109,893,772 (-)NCBI
Cytogenetic Map10q25.3NCBI
HuRef10109,682,148 - 109,791,263 (-)NCBIHuRef
CHM1_110116,338,430 - 116,448,332 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AFAP1L2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1321706
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.