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Gene: FLT3 (fms related tyrosine kinase 3) Homo sapiens
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Symbol: FLT3
Name: fms related tyrosine kinase 3
Description: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD135; CD135 antigen; fetal liver kinase 2; fetal liver kinase-2; FL cytokine receptor; FLK-2; FLK2; FLT-3; FLT3 receptor tyrosine kinase; fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; receptor-type tyrosine-protein kinase FLT3; stem cell tyrosine kinase 1; STK-1; STK1; tyrosine-protein kinase receptor FLT3
Orthologs:
Mus musculus (house mouse) : Flt3 (FMS-like tyrosine kinase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Flt3 (fms-related tyrosine kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt3 (fms related tyrosine kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT3 (fms related tyrosine kinase 3)
Canis lupus familiaris (dog) : FLT3 (fms related tyrosine kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt3 (fms related tyrosine kinase 3)
Sus scrofa (pig) : FLT3 (fms related tyrosine kinase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381328,003,274 - 28,100,592 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371328,577,411 - 28,682,904 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,475,411 - 27,572,729 (-)NCBINCBI36hg18NCBI36
Build 341327,475,752 - 27,572,703NCBI
Celera139,652,471 - 9,749,817 (-)NCBI
Cytogenetic Map13q12.2NCBI
HuRef139,398,611 - 9,496,033 (-)NCBIHuRef
CHM1_11328,546,018 - 28,643,312 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated

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Comparative Map Data
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Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on FLT3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1321714
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.