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Gene: Nck1 (non-catalytic region of tyrosine kinase adaptor protein 1) Mus musculus
Symbol: Nck1
Name: non-catalytic region of tyrosine kinase adaptor protein 1
Description: Exhibits ephrin receptor binding activity; eukaryotic initiation factor eIF2 binding activity; and protein domain specific binding activity. Involved in several processes, including plasma membrane bounded cell projection assembly; positive regulation of cellular component organization; and regulation of response to endoplasmic reticulum stress. Localizes to the cell-cell junction and vesicle membrane. Is expressed in several structures, including extraembryonic component; heart; hemolymphoid system gland; nervous system; and somite. Orthologous to human NCK1 (NCK adaptor protein 1); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6330586M15Rik; cytoplasmic protein NCK1; D230010O13Rik; Nck; NCK adaptor protein 1; Nck-1
Homo sapiens (human) : NCK1 (NCK adaptor protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nck1 (NCK adaptor protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nck1 (NCK adaptor protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NCK1 (NCK adaptor protein 1)
Canis lupus familiaris (dog) : NCK1 (NCK adaptor protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nck1 (NCK adaptor protein 1)
Sus scrofa (pig) : NCK1 (NCK adaptor protein 1)
Chlorocebus sabaeus (African green monkey) : NCK1 (NCK adaptor protein 1)
Heterocephalus glaber (naked mole-rat) : Nck1 (NCK adaptor protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl9100,492,293 - 100,546,134 (-)Ensembl
GRCm389100,494,302 - 100,546,134 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379100,395,422 - 100,446,472 (-)NCBIGRCm37mm9NCBIm37
MGSCv369100,304,355 - 100,355,405 (-)NCBImm8
Celera9100,033,773 - 100,084,727 (-)NCBICelera
Cytogenetic Map9 E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nck1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1321737
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.