Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Msh6 (mutS homolog 6) Mus musculus
Analyze
Symbol: Msh6
Name: mutS homolog 6
Description: Exhibits chromatin binding activity and damaged DNA binding activity. Contributes to guanine/thymine mispair binding activity. Involved in several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway in response to DNA damage; and somatic diversification of immunoglobulins. Localizes to MutSalpha complex and nuclear chromatin. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 5. Is expressed in several structures, including brain; early conceptus; liver; lung; and oocyte. Orthologous to human MSH6 (mutS homolog 6); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU044881; AW550279; DNA mismatch repair protein Msh6; g/T mismatch-binding protein; GTBP; Gtmbp; mutS protein homolog 6; mutS-alpha 160 kDa subunit; p160
Orthologs:
Homo sapiens (human) : MSH6 (mutS homolog 6)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Msh6 (mutS homolog 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msh6 (mutS homolog 6)
Pan paniscus (bonobo/pygmy chimpanzee) : MSH6 (mutS homolog 6)
Canis lupus familiaris (dog) : MSH6 (mutS homolog 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msh6 (mutS homolog 6)
Sus scrofa (pig) : MSH6 (mutS homolog 6)
Chlorocebus sabaeus (African green monkey) : MSH6 (mutS homolog 6)
Heterocephalus glaber (naked mole-rat) : Msh6 (mutS homolog 6)
more info ...
Related Pseudogenes: Gm11855   Msh6-rs  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1787,975,062 - 87,990,892 (+)EnsemblGRCm38mm10GRCm38
GRCm381787,975,050 - 87,990,892 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371788,374,390 - 88,390,232 (+)NCBIGRCm37mm9NCBIm37
MGSCv361787,883,410 - 87,899,389 (+)NCBImm8
Celera1792,385,348 - 92,401,193 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1757.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model