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Gene: U2AF2 (U2 small nuclear RNA auxiliary factor 2) Homo sapiens
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Symbol: U2AF2
Name: U2 small nuclear RNA auxiliary factor 2
Description: Exhibits enzyme binding activity and pre-mRNA 3'-splice site binding activity. Involved in mRNA splicing, via spliceosome; negative regulation of protein ubiquitination; and regulation of RNA splicing. Localizes to the U2-type prespliceosome; U2AF; and nuclear speck. Colocalizes with the Prp19 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hU2AF(65); hU2AF65; splicing factor U2AF 65 kD subunit; splicing factor U2AF 65 kDa subunit; U2 (RNU2) small nuclear RNA auxiliary factor 2; U2 auxiliary factor 65 kDa subunit; U2 small nuclear ribonucleoprotein auxiliary factor (65kD); U2 snRNP auxiliary factor large subunit; U2AF65
Orthologs:
Mus musculus (house mouse) : U2af2 (U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : U2af2 (U2 small nuclear RNA auxiliary factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : U2af2 (U2 small nuclear RNA auxiliary factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : U2AF2 (U2 small nuclear RNA auxiliary factor 2)
Canis lupus familiaris (dog) : U2AF2 (U2 small nuclear RNA auxiliary factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : U2af2 (U2 small nuclear RNA auxiliary factor 2)
Sus scrofa (pig) : U2AF2 (U2 small nuclear RNA auxiliary factor 2)
Chlorocebus sabaeus (African green monkey) : U2AF2 (U2 small nuclear RNA auxiliary factor 2)
Heterocephalus glaber (naked mole-rat) : U2af2 (U2 small nuclear RNA auxiliary factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1955,654,146 - 55,674,715 (+)EnsemblGRCh38hg38GRCh38
GRCh381955,654,132 - 55,674,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371956,165,416 - 56,186,082 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,857,228 - 60,877,894 (+)NCBINCBI36hg18NCBI36
Build 341960,857,227 - 60,877,893NCBI
Celera1953,207,708 - 53,228,376 (+)NCBI
Cytogenetic Map19q13.42NCBI
HuRef1952,475,902 - 52,497,114 (+)NCBIHuRef
CHM1_11956,159,092 - 56,179,747 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on U2AF2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1321740
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.