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Gene: HSF4 (heat shock transcription factor 4) Homo sapiens
Symbol: HSF4
Name: heat shock transcription factor 4
Description: Exhibits protein phosphatase binding activity. Predicted to be involved in positive regulation of transcription from RNA polymerase II promoter in response to heat stress. Localizes to the nuclear speck. Implicated in cataract and cataract 5 multiple types.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cataract, Marner; CTM; CTRCT5; heat shock factor protein 4; hHSF4; HSF 4; HSTF 4
Mus musculus (house mouse) : Hsf4 (heat shock transcription factor 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hsf4 (heat shock transcription factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsf4 (heat shock transcription factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : HSF4 (heat shock transcription factor 4)
Canis lupus familiaris (dog) : HSF4 (heat shock transcription factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsf4 (heat shock transcription factor 4)
Sus scrofa (pig) : LOC100523672 (heat shock factor protein 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381667,163,761 - 67,169,941 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371667,197,288 - 67,203,848 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,754,858 - 65,761,349 (+)NCBINCBI36hg18NCBI36
Build 341665,756,216 - 65,761,347NCBI
Celera1651,705,531 - 51,712,092 (+)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1653,070,801 - 53,077,037 (+)NCBIHuRef
CHM1_11668,604,606 - 68,611,167 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HSF4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1321924
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.