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Gene: TERF2 (telomeric repeat binding factor 2) Homo sapiens
Symbol: TERF2
Name: telomeric repeat binding factor 2
Description: Exhibits several functions, including protein C-terminus binding activity; protein homodimerization activity; and telomeric DNA binding activity. Contributes to telomerase activity. Involved in several processes, including negative regulation of hydrolase activity; negative regulation of telomere maintenance; and telomere maintenance. Localizes to the nuclear body and shelterin complex. Colocalizes with the Mre11 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: telomeric DNA-binding protein; telomeric repeat binding protein 2; telomeric repeat-binding factor 2; TRBF2; TRF2; TTAGGG repeat-binding factor 2
Mus musculus (house mouse) : Terf2 (telomeric repeat binding factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Terf2 (telomeric repeat binding factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Terf2 (telomeric repeat binding factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TERF2 (telomeric repeat binding factor 2)
Canis lupus familiaris (dog) : TERF2 (telomeric repeat binding factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Terf2 (telomeric repeat binding factor 2)
Sus scrofa (pig) : TERF2 (telomeric repeat binding factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381669,355,567 - 69,386,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371669,389,464 - 69,419,891 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361667,947,032 - 67,977,374 (-)NCBINCBI36hg18NCBI36
Build 341667,947,035 - 67,977,374NCBI
Celera1653,904,070 - 53,934,402 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1655,267,237 - 55,298,105 (-)NCBIHuRef
CHM1_11670,797,479 - 70,827,880 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TERF2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322035
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.