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Gene: TERF2 (telomeric repeat binding factor 2) Homo sapiens
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Symbol: TERF2
Name: telomeric repeat binding factor 2
Description: Exhibits several functions, including protein C-terminus binding activity; protein homodimerization activity; and telomeric DNA binding activity. Contributes to telomerase activity. Involved in several processes, including negative regulation of hydrolase activity; negative regulation of telomere maintenance; and telomere maintenance. Localizes to the nuclear body and shelterin complex. Colocalizes with the Mre11 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: telomeric DNA-binding protein; telomeric repeat binding protein 2; telomeric repeat-binding factor 2; TRBF2; TRF2; TTAGGG repeat-binding factor 2
Orthologs:
Mus musculus (house mouse) : Terf2 (telomeric repeat binding factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Terf2 (telomeric repeat binding factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Terf2 (telomeric repeat binding factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TERF2 (telomeric repeat binding factor 2)
Canis lupus familiaris (dog) : TERF2 (telomeric repeat binding factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Terf2 (telomeric repeat binding factor 2)
Sus scrofa (pig) : TERF2 (telomeric repeat binding factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381669,355,567 - 69,386,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371669,389,464 - 69,419,891 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361667,947,032 - 67,977,374 (-)NCBINCBI36hg18NCBI36
Build 341667,947,035 - 67,977,374NCBI
Celera1653,904,070 - 53,934,402 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1655,267,237 - 55,298,105 (-)NCBIHuRef
CHM1_11670,797,479 - 70,827,880 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TERF2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322035
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.