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Gene: TARDBP (TAR DNA binding protein) Homo sapiens
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Symbol: TARDBP
Name: TAR DNA binding protein
Description: Exhibits double-stranded DNA binding activity; identical protein binding activity; and mRNA 3'-UTR binding activity. Involved in several processes, including negative regulation by host of viral transcription; negative regulation of macromolecule metabolic process; and nuclear inner membrane organization. Localizes to the nucleoplasm. Implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Biomarker of Lewy body dementia; neurodegenerative disease (multiple); and progressive supranuclear palsy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALS10; TAR DNA-binding protein 43; TAR DNA-binding protein-43; TDP-43
Orthologs:
Mus musculus (house mouse) : Tardbp (TAR DNA binding protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tardbp (TAR DNA binding protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tardbp (TAR DNA binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TARDBP (TAR DNA binding protein)
Canis lupus familiaris (dog) : TARDBP (TAR DNA binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tardbp (TAR DNA binding protein)
Sus scrofa (pig) : TARDBP (TAR DNA binding protein)
Chlorocebus sabaeus (African green monkey) : TARDBP (TAR DNA binding protein)
Heterocephalus glaber (naked mole-rat) : Tardbp (TAR DNA binding protein)
more info ...
Related Pseudogenes: TARDBPP1   TARDBPP2  
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SD-Tg(TRE-TARDBP-M337V)  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl111,012,662 - 11,030,528 (+)Ensembl
GRCh38 Ensembl111,012,344 - 11,026,420 (+)Ensembl
GRCh38111,012,654 - 11,030,528 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,072,462 - 11,085,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36110,995,266 - 11,008,136 (+)NCBINCBI36hg18NCBI36
Build 34111,006,944 - 11,019,814NCBI
Celera110,184,976 - 10,197,861 (+)NCBI
Cytogenetic Map1p36.22NCBI
HuRef110,224,341 - 10,237,229 (+)NCBIHuRef
CHM1_1111,060,321 - 11,073,209 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TARDBP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322081
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.