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Gene: SORL1 (sortilin related receptor 1) Homo sapiens
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Symbol: SORL1
Name: sortilin related receptor 1
Description: Exhibits ADP-ribosylation factor binding activity; amyloid-beta binding activity; and low-density lipoprotein particle binding activity. Involved in several processes, including negative regulation of amyloid precursor protein catabolic process; positive regulation of intracellular transport; and protein localization to organelle. Localizes to several cellular components, including the Golgi subcompartment; endosome; and nuclear envelope lumen. Implicated in Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C11orf32; chromosome 11 open reading frame 32; FLJ21930; FLJ39258; gp250; LDLR relative with 11 ligand-binding repeats; low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11; LRP9; mosaic protein LR11; SORLA; SorLA-1; sortilin-related receptor; sortilin-related receptor containing LDLR class A repeats; sortilin-related receptor, L(DLR class) A repeats containing; sortilin-related receptor, L(DLR class) A repeats-containing; sorting protein-related receptor containing LDLR class A repeats
Orthologs:
Mus musculus (house mouse) : Sorl1 (sortilin-related receptor, LDLR class A repeats-containing)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sorl1 (sortilin related receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sorl1 (sortilin related receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SORL1 (sortilin related receptor 1)
Canis lupus familiaris (dog) : SORL1 (sortilin related receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sorl1 (sortilin related receptor 1)
Sus scrofa (pig) : SORL1 (sortilin related receptor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: In some of the published literature, this gene has been incorrectly associated with the LRP9 alias, but the LRP9 alias more correctly refers to Gene ID 26020, LRP10. [05 May 2010]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811121,452,314 - 121,633,763 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711121,322,912 - 121,504,471 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611120,828,130 - 121,005,621 (+)NCBINCBI36hg18NCBI36
Build 3411120,828,129 - 121,005,610NCBI
Celera11118,482,367 - 118,662,804 (+)NCBI
Cytogenetic Map11q24.1NCBI
HuRef11117,266,146 - 117,448,320 (+)NCBIHuRef
CHM1_111121,210,607 - 121,392,157 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SORL1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322123
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.