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Gene: IDUA (alpha-L-iduronidase) Homo sapiens
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Symbol: IDUA
Name: alpha-L-iduronidase
CRRD ID: 1322129
Description: Exhibits L-iduronidase activity. Involved in dermatan sulfate catabolic process and heparin catabolic process. Localizes to extracellular exosome. Implicated in Scheie syndrome; mucopolysaccharidosis I; mucopolysaccharidosis Ih; and mucopolysaccharidosis Ih/s. Biomarker of mucopolysaccharidosis I.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IDA; iduronidase alpha-L-; iduronidase, alpha-L-; MPS1; MPSI; mucopolysaccharidosis type I
Orthologs:
Mus musculus (house mouse) : Idua (iduronidase, alpha-L)  MGI  Alliance
Rattus norvegicus (Norway rat) : Idua (alpha-L-iduronidase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Idua (alpha-L-iduronidase)
Pan paniscus (bonobo/pygmy chimpanzee) : IDUA (alpha-L-iduronidase)
Canis lupus familiaris (dog) : IDUA (alpha-L-iduronidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Idua (alpha-L-iduronidase)
Sus scrofa (pig) : IDUA (alpha-L-iduronidase)
Chlorocebus sabaeus (African green monkey) : IDUA (alpha-L-iduronidase)
Heterocephalus glaber (naked mole-rat) : Idua (alpha-L-iduronidase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4986,997 - 1,004,564 (+)EnsemblGRCh38hg38GRCh38
GRCh384986,997 - 1,004,564 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374980,785 - 998,317 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364970,785 - 988,317 (+)NCBINCBI36hg18NCBI36
Build 344970,614 - 988,146NCBI
Celera4917,731 - 935,177 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef4952,003 - 969,463 (+)NCBIHuRef
CHM1_14980,568 - 998,128 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on IDUA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322129
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.