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Gene: CST5 (cystatin D) Homo sapiens
Symbol: CST5
Name: cystatin D
Description: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cystatin 5; cystatin-5; cystatin-D; cysteine-proteinase inhibitor; MGC71922
Mus musculus (house mouse) : Cst10 (cystatin 10 (chondrocytes))  MGI  Alliance
Rattus norvegicus (Norway rat) : Cst5 (cystatin D)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CST5 (cystatin D)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382023,875,935 - 23,879,743 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372023,856,572 - 23,860,380 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362023,804,572 - 23,808,380 (-)NCBINCBI36hg18NCBI36
Build 342023,804,792 - 23,808,371NCBI
Celera2023,929,951 - 23,933,759 (-)NCBI
Cytogenetic Map20p11.21NCBI
HuRef2023,813,604 - 23,817,412 (-)NCBIHuRef
CHM1_12023,856,749 - 23,860,557 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CST5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322184
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.