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Gene: EXOSC4 (exosome component 4) Homo sapiens
Symbol: EXOSC4
Name: exosome component 4
Description: Exhibits mRNA 3'-UTR AU-rich region binding activity. Involved in defense response to virus; nucleic acid metabolic process; and positive regulation of cell growth. Localizes to several cellular components, including the exosome (RNase complex); intermediate filament cytoskeleton; and transcriptionally active chromatin; INTERACTS WITH atrazine; benzo[a]pyrene; cadmium atom.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: exosome complex component RRP41; exosome complex exonuclease RRP41; exosome component Rrp41; FLJ20591; hRrp41p; p12A; ribosomal RNA-processing protein 41; RRP41; RRP41A; Rrp41p; SKI6; Ski6p
Mus musculus (house mouse) : Exosc4 (exosome component 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Exosc4 (exosome component 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Exosc4 (exosome component 4)
Pan paniscus (bonobo/pygmy chimpanzee) : EXOSC4 (exosome component 4)
Canis lupus familiaris (dog) : EXOSC4 (exosome component 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Exosc4 (exosome component 4)
Sus scrofa (pig) : EXOSC4 (exosome component 4)
Chlorocebus sabaeus (African green monkey) : EXOSC4 (exosome component 4)
Heterocephalus glaber (naked mole-rat) : Exosc4 (exosome component 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8144,078,648 - 144,080,648 (+)EnsemblGRCh38hg38GRCh38
GRCh388144,064,061 - 144,080,648 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378145,133,522 - 145,135,551 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,205,510 - 145,207,539 (+)NCBINCBI36hg18NCBI36
Build 348145,205,509 - 145,207,538NCBI
Celera8141,471,120 - 141,473,149 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,409,424 - 140,411,453 (+)NCBIHuRef
CHM1_18145,173,774 - 145,175,803 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on EXOSC4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322197
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.