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Gene: TET1 (tet methylcytosine dioxygenase 1) Homo sapiens
Symbol: TET1
Name: tet methylcytosine dioxygenase 1
Description: Exhibits methyl-CpG binding activity; methylcytosine dioxygenase activity; and transition metal ion binding activity. Involved in DNA demethylation; positive regulation of cell population proliferation; and regulation of chromatin organization. Predicted to localize to nucleus. Biomarker of hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bA119F7.1; CXXC finger 6; CXXC zinc finger 6; CXXC-type zinc finger protein 6; CXXC6; FLJ10839; FLJ41442; KIAA1676; LCX; leukemia-associated protein with a CXXC domain; methylcytosine dioxygenase TET1; MLL-TET1; ten-eleven translocation 1 gene protein; ten-eleven translocation-1; tet oncogene 1; TET1 splice variant VP_DE4; TET1 splice variant VP_DE456; TET1-MLL
Mus musculus (house mouse) : Tet1 (tet methylcytosine dioxygenase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tet1 (tet methylcytosine dioxygenase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tet1 (tet methylcytosine dioxygenase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TET1 (tet methylcytosine dioxygenase 1)
Canis lupus familiaris (dog) : TET1 (tet methylcytosine dioxygenase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tet1 (tet methylcytosine dioxygenase 1)
Sus scrofa (pig) : TET1 (tet methylcytosine dioxygenase 1)
Chlorocebus sabaeus (African green monkey) : TET1 (tet methylcytosine dioxygenase 1)
Heterocephalus glaber (naked mole-rat) : Tet1 (tet methylcytosine dioxygenase 1)
more info ...
Related Pseudogenes: TET1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1068,560,337 - 68,694,487 (+)EnsemblGRCh38hg38GRCh38
GRCh381068,560,337 - 68,700,794 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371070,320,117 - 70,454,239 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,990,123 - 70,124,245 (+)NCBINCBI36hg18NCBI36
Build 341069,990,418 - 70,123,454NCBI
Celera1063,596,035 - 63,730,160 (+)NCBI
Cytogenetic Map10q21.3NCBI
HuRef1064,321,678 - 64,456,326 (+)NCBIHuRef
CHM1_11070,602,173 - 70,737,025 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TET1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322209
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.