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Gene: MECOM (MDS1 and EVI1 complex locus) Homo sapiens
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Symbol: MECOM
Name: MDS1 and EVI1 complex locus
Description: Exhibits DNA-binding transcription factor activity and protein homodimerization activity. Involved in several processes, including negative regulation of JNK cascade; negative regulation of programmed cell death; and regulation of transcription, DNA-templated. Localizes to the nuclear speck. Colocalizes with the histone deacetylase complex. Implicated in myeloid neoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AML1-EVI-1; AML1-EVI-1 fusion protein; ecotropic viral integration site 1; ecotropic virus integration site 1 protein homolog; EVI1; histone-lysine N-methyltransferase MECOM; KMT8E; MDS1; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; MDS1-EVI1; MGC163392; MGC97004; myelodysplasia syndrome 1; myelodysplasia syndrome 1 protein; myelodysplasia syndrome-associated protein 1; oncogene EVI1; PR domain 3; PRDM3; RUSAT2; zinc finger protein Evi1
Orthologs:
Mus musculus (house mouse) : Mecom (MDS1 and EVI1 complex locus)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mecom (MDS1 and EVI1 complex locus)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mecom (MDS1 and EVI1 complex locus)
Pan paniscus (bonobo/pygmy chimpanzee) : MECOM (MDS1 and EVI1 complex locus)
Canis lupus familiaris (dog) : MECOM (MDS1 and EVI1 complex locus)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mecom (MDS1 and EVI1 complex locus)
Sus scrofa (pig) : MECOM (MDS1 and EVI1 complex locus)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383169,083,499 - 169,663,781 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373168,801,287 - 169,381,563 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363170,283,981 - 170,348,216 (-)NCBINCBI36hg18NCBI36
Build 343170,285,251 - 170,346,795NCBI
Celera3167,199,811 - 167,780,346 (-)NCBI
Cytogenetic Map3q26.2NCBI
HuRef3166,172,067 - 166,751,440 (-)NCBIHuRef
CHM1_13168,763,814 - 169,344,623 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on MECOM
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322216
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.