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Gene: Cradd (CASP2 and RIPK1 domain containing adaptor with death domain) Mus musculus
Symbol: Cradd
Name: CASP2 and RIPK1 domain containing adaptor with death domain
Description: Predicted to have death domain binding activity; protease binding activity; and protein binding activity, bridging. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of apoptotic signaling pathway. Localizes to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain); PARTICIPATES IN ceramide signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CASP2 and RIPK1 domain-containing adaptor with death domain; caspase and RIP adapter with death domain; death domain-containing protein CRADD; RAIDD; RIP-associated protein with a death domain
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381095,174,739 - 95,324,138 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371094,637,380 - 94,786,731 (-)NCBIGRCm37mm9NCBIm37
MGSCv361094,604,434 - 94,753,785 (-)NCBImm8
Celera1097,149,089 - 97,298,972 (-)NCBICelera
Cytogenetic Map10 C2NCBI
cM Map1049.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cradd
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322238
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.