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Gene: TBX2 (T-box transcription factor 2) Homo sapiens
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Symbol: TBX2
Name: T-box transcription factor 2
CRRD ID: 1322243
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular senescence; negative regulation of transcription by RNA polymerase II; and positive regulation of cell population proliferation. Localizes to nucleus. Implicated in vertebral anomalies and variable endocrine and T-cell dysfunction.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ10169; T-box 2; T-box protein 2; T-box transcription factor TBX2; VETD
Orthologs:
Mus musculus (house mouse) : Tbx2 (T-box 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tbx2 (T-box transcription factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tbx2 (T-box transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TBX2 (T-box transcription factor 2)
Canis lupus familiaris (dog) : TBX2 (T-box transcription factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tbx2 (T-box transcription factor 2)
Sus scrofa (pig) : TBX2 (T-box transcription factor 2)
Chlorocebus sabaeus (African green monkey) : TBX2 (T-box transcription factor 2)
Heterocephalus glaber (naked mole-rat) : Tbx2 (T-box transcription factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1761,399,843 - 61,409,466 (+)EnsemblGRCh38hg38GRCh38
GRCh381761,399,843 - 61,409,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371759,477,257 - 59,486,827 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361756,832,039 - 56,841,609 (+)NCBINCBI36hg18NCBI36
Build 341756,832,038 - 56,841,607NCBI
Celera1758,578,306 - 58,587,856 (+)NCBI
Cytogenetic Map17q23.2NCBI
HuRef1754,844,115 - 54,856,411 (+)NCBIHuRef
CHM1_11759,541,779 - 59,551,327 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TBX2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322243
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.